TY - JOUR
T1 - Effects of doxapram on myocardial repolarization in anesthetized rats
AU - Nomura, Hiroko
AU - Kochiyama, Yoshie
AU - Irie, Tohru
AU - Miyata, Masafumi
AU - Kusuki, Hirofumi
AU - Tanaka, Akiko
AU - Boda, Hiroko
AU - Yamazaki, Toshio
AU - Hata, Tadayoshi
AU - Kuriki, Marina
AU - Irikura, Mitsuru
AU - Takeuchi, Masatomo
AU - Nagaoka, Shunji
PY - 2009
Y1 - 2009
N2 - The inhibitory effects of doxapram, a respiratory accelerator, on the cardiac impulse-conducting system and myocardial repolarization time were investigated in anesthetized animals using electrocardiography. Doxapram prolonged QT and QTcE which are indicative of the myocardial repolarization time, in a dose-dependent manner in rats anesthetized by sevoflurane. However, prolongation of the atrioventricular conduction time was not observed, even at the maximum dose (10 mg/kg), and deterioration of either the QT variability index or QT variability ratio, indices of time-dependent variation in cardiac cycle and myocardial repolarization, was not observed. Doxapram prolonged the myocardial repolarization time at high doses, but maintained the physiologically valid QT/RR relationship and did not increase proarrhythmia.
AB - The inhibitory effects of doxapram, a respiratory accelerator, on the cardiac impulse-conducting system and myocardial repolarization time were investigated in anesthetized animals using electrocardiography. Doxapram prolonged QT and QTcE which are indicative of the myocardial repolarization time, in a dose-dependent manner in rats anesthetized by sevoflurane. However, prolongation of the atrioventricular conduction time was not observed, even at the maximum dose (10 mg/kg), and deterioration of either the QT variability index or QT variability ratio, indices of time-dependent variation in cardiac cycle and myocardial repolarization, was not observed. Doxapram prolonged the myocardial repolarization time at high doses, but maintained the physiologically valid QT/RR relationship and did not increase proarrhythmia.
UR - https://www.scopus.com/pages/publications/70350077985
UR - https://www.scopus.com/pages/publications/70350077985#tab=citedBy
M3 - Article
AN - SCOPUS:70350077985
SN - 0289-8020
VL - 30
SP - 1367
EP - 1374
JO - Therapeutic Research
JF - Therapeutic Research
IS - 8
ER -