Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice

M. Hiramatsu, Toshitaka Nabeshima, H. Furukawa, T. Kameyama

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of enkephalin analogs, morphine and naloxone were investigated on phencyclidine (PCP)-induced stereotyped behaviors and motor incoordination in mice. Enkephalin analogs (D-ala2-methionine-enkephalinamide; DAMEA 25 μg/mouse and D-ala2-leucine-enkephalin; DALE 12,5 μg/mouse, i.c.v.) significantly increased the degree and duration of pivotting at 10 mg/kg PCP. Morphine (2.5 and 5.0 mg/kg) also potenciated PCP-induced pivotting. On the contrary, naloxone (5.0 mg/kg) partially antagonized PCP-induced pivotting. PCP-induced motor incoordination was enhanced by DAMEA (25 μg/mouse), Dale (12.5 μg/mouse) and morphine (2.5 μg/kg), but not naloxone (5.0 mg/kg). These resuls suggest that an involvement of central opioid receptor mechanisms in the mediation of PCP-induced behaviours in mice.

Original languageEnglish
Pages (from-to)161-173
Number of pages13
JournalResearch Communications in Substances of Abuse
Volume5
Issue number3
Publication statusPublished - 01-12-1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)

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