Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice

M. Hiramatsu; T. Nabeshima; H. Furukawa; T. Kameyama

Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice

M. Hiramatsu, T. Nabeshima, H. Furukawa, T. Kameyama

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of enkephalin analogs, morphine and naloxone were investigated on phencyclidine (PCP)-induced stereotyped behaviors and motor incoordination in mice. Enkephalin analogs (D-ala²-methionine-enkephalinamide; DAMEA 25 μg/mouse and D-ala²-leucine-enkephalin; DALE 12,5 μg/mouse, i.c.v.) significantly increased the degree and duration of pivotting at 10 mg/kg PCP. Morphine (2.5 and 5.0 mg/kg) also potenciated PCP-induced pivotting. On the contrary, naloxone (5.0 mg/kg) partially antagonized PCP-induced pivotting. PCP-induced motor incoordination was enhanced by DAMEA (25 μg/mouse), Dale (12.5 μg/mouse) and morphine (2.5 μg/kg), but not naloxone (5.0 mg/kg). These resuls suggest that an involvement of central opioid receptor mechanisms in the mediation of PCP-induced behaviours in mice.

Original language	English
Pages (from-to)	161-173
Number of pages	13
Journal	Research Communications in Substances of Abuse
Volume	5
Issue number	3
Publication status	Published - 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Medicine (miscellaneous)

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@article{f0e8d4c0e35846499aca53f1a8b9aaf5,

title = "Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice",

abstract = "The effects of enkephalin analogs, morphine and naloxone were investigated on phencyclidine (PCP)-induced stereotyped behaviors and motor incoordination in mice. Enkephalin analogs (D-ala2-methionine-enkephalinamide; DAMEA 25 μg/mouse and D-ala2-leucine-enkephalin; DALE 12,5 μg/mouse, i.c.v.) significantly increased the degree and duration of pivotting at 10 mg/kg PCP. Morphine (2.5 and 5.0 mg/kg) also potenciated PCP-induced pivotting. On the contrary, naloxone (5.0 mg/kg) partially antagonized PCP-induced pivotting. PCP-induced motor incoordination was enhanced by DAMEA (25 μg/mouse), Dale (12.5 μg/mouse) and morphine (2.5 μg/kg), but not naloxone (5.0 mg/kg). These resuls suggest that an involvement of central opioid receptor mechanisms in the mediation of PCP-induced behaviours in mice.",

author = "M. Hiramatsu and T. Nabeshima and H. Furukawa and T. Kameyama",

year = "1984",

language = "English",

volume = "5",

pages = "161--173",

journal = "Research Communications in Substances of Abuse",

issn = "0193-0818",

publisher = "PJD Publications Ltd",

number = "3",

}

TY - JOUR

T1 - Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice

AU - Hiramatsu, M.

AU - Nabeshima, T.

AU - Furukawa, H.

AU - Kameyama, T.

PY - 1984

Y1 - 1984

N2 - The effects of enkephalin analogs, morphine and naloxone were investigated on phencyclidine (PCP)-induced stereotyped behaviors and motor incoordination in mice. Enkephalin analogs (D-ala2-methionine-enkephalinamide; DAMEA 25 μg/mouse and D-ala2-leucine-enkephalin; DALE 12,5 μg/mouse, i.c.v.) significantly increased the degree and duration of pivotting at 10 mg/kg PCP. Morphine (2.5 and 5.0 mg/kg) also potenciated PCP-induced pivotting. On the contrary, naloxone (5.0 mg/kg) partially antagonized PCP-induced pivotting. PCP-induced motor incoordination was enhanced by DAMEA (25 μg/mouse), Dale (12.5 μg/mouse) and morphine (2.5 μg/kg), but not naloxone (5.0 mg/kg). These resuls suggest that an involvement of central opioid receptor mechanisms in the mediation of PCP-induced behaviours in mice.

AB - The effects of enkephalin analogs, morphine and naloxone were investigated on phencyclidine (PCP)-induced stereotyped behaviors and motor incoordination in mice. Enkephalin analogs (D-ala2-methionine-enkephalinamide; DAMEA 25 μg/mouse and D-ala2-leucine-enkephalin; DALE 12,5 μg/mouse, i.c.v.) significantly increased the degree and duration of pivotting at 10 mg/kg PCP. Morphine (2.5 and 5.0 mg/kg) also potenciated PCP-induced pivotting. On the contrary, naloxone (5.0 mg/kg) partially antagonized PCP-induced pivotting. PCP-induced motor incoordination was enhanced by DAMEA (25 μg/mouse), Dale (12.5 μg/mouse) and morphine (2.5 μg/kg), but not naloxone (5.0 mg/kg). These resuls suggest that an involvement of central opioid receptor mechanisms in the mediation of PCP-induced behaviours in mice.

UR - https://www.scopus.com/pages/publications/0021675315

UR - https://www.scopus.com/inward/citedby.url?scp=0021675315&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0021675315

SN - 0193-0818

VL - 5

SP - 161

EP - 173

JO - Research Communications in Substances of Abuse

JF - Research Communications in Substances of Abuse

IS - 3

ER -

Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice

Abstract

All Science Journal Classification (ASJC) codes

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