TY - JOUR
T1 - Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice
AU - Shin, E. J.
AU - Kim, J. M.
AU - Nguyen, X. K.T.
AU - Nguyen, T. T.L.
AU - Lee, S. Y.
AU - Jung, J. H.
AU - Kim, M. J.
AU - Whang, W. K.
AU - Yamada, K.
AU - Nabeshima, Toshitaka
AU - Kim, H. C.
PY - 2011
Y1 - 2011
N2 - It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.
AB - It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.
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U2 - 10.2174/157015911795017263
DO - 10.2174/157015911795017263
M3 - Article
C2 - 21886599
AN - SCOPUS:79953033161
SN - 1570-159X
VL - 9
SP - 247
EP - 250
JO - Current Neuropharmacology
JF - Current Neuropharmacology
IS - 1
ER -
