Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin, J. M. Kim, X. K.T. Nguyen, T. T.L. Nguyen, S. Y. Lee, J. H. Jung, M. J. Kim, W. K. Whang, K. Yamada, Toshitaka Nabeshima, H. C. Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

It has been demonstrated that 5-HT 1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT 1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT 1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT 1A in mice.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011
Externally publishedYes

Fingerprint

Gastrodia
Phencyclidine
Psychotic Disorders
Schizophrenia
Receptor, Serotonin, 5-HT1A
8-Hydroxy-2-(di-n-propylamino)tetralin
Interpersonal Relations
Antipsychotic Agents
Serotonin

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Shin, E. J., Kim, J. M., Nguyen, X. K. T., Nguyen, T. T. L., Lee, S. Y., Jung, J. H., ... Kim, H. C. (2011). Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. Current Neuropharmacology, 9(1), 247-250. https://doi.org/10.2174/157015911795017263
Shin, E. J. ; Kim, J. M. ; Nguyen, X. K.T. ; Nguyen, T. T.L. ; Lee, S. Y. ; Jung, J. H. ; Kim, M. J. ; Whang, W. K. ; Yamada, K. ; Nabeshima, Toshitaka ; Kim, H. C. / Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 1. pp. 247-250.
@article{2cb0415de62a4c9f8d4ccdc733388d86,
title = "Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice",
abstract = "It has been demonstrated that 5-HT 1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT 1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT 1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT 1A in mice.",
author = "Shin, {E. J.} and Kim, {J. M.} and Nguyen, {X. K.T.} and Nguyen, {T. T.L.} and Lee, {S. Y.} and Jung, {J. H.} and Kim, {M. J.} and Whang, {W. K.} and K. Yamada and Toshitaka Nabeshima and Kim, {H. C.}",
year = "2011",
month = "3",
day = "30",
doi = "10.2174/157015911795017263",
language = "English",
volume = "9",
pages = "247--250",
journal = "Current Neuropharmacology",
issn = "1570-159X",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

Shin, EJ, Kim, JM, Nguyen, XKT, Nguyen, TTL, Lee, SY, Jung, JH, Kim, MJ, Whang, WK, Yamada, K, Nabeshima, T & Kim, HC 2011, 'Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice', Current Neuropharmacology, vol. 9, no. 1, pp. 247-250. https://doi.org/10.2174/157015911795017263

Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. / Shin, E. J.; Kim, J. M.; Nguyen, X. K.T.; Nguyen, T. T.L.; Lee, S. Y.; Jung, J. H.; Kim, M. J.; Whang, W. K.; Yamada, K.; Nabeshima, Toshitaka; Kim, H. C.

In: Current Neuropharmacology, Vol. 9, No. 1, 30.03.2011, p. 247-250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

AU - Shin, E. J.

AU - Kim, J. M.

AU - Nguyen, X. K.T.

AU - Nguyen, T. T.L.

AU - Lee, S. Y.

AU - Jung, J. H.

AU - Kim, M. J.

AU - Whang, W. K.

AU - Yamada, K.

AU - Nabeshima, Toshitaka

AU - Kim, H. C.

PY - 2011/3/30

Y1 - 2011/3/30

N2 - It has been demonstrated that 5-HT 1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT 1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT 1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT 1A in mice.

AB - It has been demonstrated that 5-HT 1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT 1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT 1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT 1A in mice.

UR - http://www.scopus.com/inward/record.url?scp=79953033161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953033161&partnerID=8YFLogxK

U2 - 10.2174/157015911795017263

DO - 10.2174/157015911795017263

M3 - Article

VL - 9

SP - 247

EP - 250

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 1

ER -