Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin, J. M. Kim, X. K.T. Nguyen, T. T.L. Nguyen, S. Y. Lee, J. H. Jung, M. J. Kim, W. K. Whang, K. Yamada, T. Nabeshima, H. C. Kim

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6 Citations (Scopus)

Abstract

It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalCurrent Neuropharmacology
Volume9
Issue number1
DOIs
Publication statusPublished - 30-03-2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Shin, E. J., Kim, J. M., Nguyen, X. K. T., Nguyen, T. T. L., Lee, S. Y., Jung, J. H., Kim, M. J., Whang, W. K., Yamada, K., Nabeshima, T., & Kim, H. C. (2011). Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. Current Neuropharmacology, 9(1), 247-250. https://doi.org/10.2174/157015911795017263