Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin; J. M. Kim; X. K.T. Nguyen; T. T.L. Nguyen; S. Y. Lee; J. H. Jung; M. J. Kim; W. K. Whang; K. Yamada; Toshitaka Nabeshima; H. C. Kim

doi:10.2174/157015911795017263

Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin
, J. M. Kim
, X. K.T. Nguyen
, T. T.L. Nguyen
, S. Y. Lee
, J. H. Jung
, M. J. Kim
, W. K. Whang
, K. Yamada
, Toshitaka Nabeshima
, H. C. Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

It has been demonstrated that 5-HT_1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT_1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT_1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT_1A in mice.

Original language	English
Pages (from-to)	247-250
Number of pages	4
Journal	Current Neuropharmacology
Volume	9
Issue number	1
DOIs	https://doi.org/10.2174/157015911795017263
Publication status	Published - 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/157015911795017263

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title = "Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice",

abstract = "It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.",

author = "Shin, \{E. J.\} and Kim, \{J. M.\} and Nguyen, \{X. K.T.\} and Nguyen, \{T. T.L.\} and Lee, \{S. Y.\} and Jung, \{J. H.\} and Kim, \{M. J.\} and Whang, \{W. K.\} and K. Yamada and Toshitaka Nabeshima and Kim, \{H. C.\}",

year = "2011",

doi = "10.2174/157015911795017263",

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pages = "247--250",

journal = "Current Neuropharmacology",

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T1 - Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

AU - Shin, E. J.

AU - Kim, J. M.

AU - Nguyen, X. K.T.

AU - Nguyen, T. T.L.

AU - Lee, S. Y.

AU - Jung, J. H.

AU - Kim, M. J.

AU - Whang, W. K.

AU - Yamada, K.

AU - Nabeshima, Toshitaka

AU - Kim, H. C.

PY - 2011

Y1 - 2011

N2 - It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

AB - It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

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Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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