Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin; J. M. Kim; X. K.T. Nguyen; T. T.L. Nguyen; S. Y. Lee; J. H. Jung; M. J. Kim; W. K. Whang; K. Yamada; Toshitaka Nabeshima; H. C. Kim

doi:10.2174/157015911795017263

Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

E. J. Shin
, J. M. Kim
, X. K.T. Nguyen
, T. T.L. Nguyen
, S. Y. Lee
, J. H. Jung
, M. J. Kim
, W. K. Whang
, K. Yamada
, Toshitaka Nabeshima
, H. C. Kim

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

It has been demonstrated that 5-HT_1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT_1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT_1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT_1A in mice.

Original language	English
Pages (from-to)	247-250
Number of pages	4
Journal	Current Neuropharmacology
Volume	9
Issue number	1
DOIs	https://doi.org/10.2174/157015911795017263
Publication status	Published - 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

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10.2174/157015911795017263

Cite this

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title = "Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice",

abstract = "It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.",

author = "Shin, \{E. J.\} and Kim, \{J. M.\} and Nguyen, \{X. K.T.\} and Nguyen, \{T. T.L.\} and Lee, \{S. Y.\} and Jung, \{J. H.\} and Kim, \{M. J.\} and Whang, \{W. K.\} and K. Yamada and Toshitaka Nabeshima and Kim, \{H. C.\}",

year = "2011",

doi = "10.2174/157015911795017263",

language = "English",

volume = "9",

pages = "247--250",

journal = "Current Neuropharmacology",

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TY - JOUR

T1 - Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

AU - Shin, E. J.

AU - Kim, J. M.

AU - Nguyen, X. K.T.

AU - Nguyen, T. T.L.

AU - Lee, S. Y.

AU - Jung, J. H.

AU - Kim, M. J.

AU - Whang, W. K.

AU - Yamada, K.

AU - Nabeshima, Toshitaka

AU - Kim, H. C.

PY - 2011

Y1 - 2011

N2 - It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

AB - It has been demonstrated that 5-HT1A receptors play an important role in the pathophysiology of schizophrenia. Because Gastrodia elata Bl (GE) modulates the serotonergic system, we examined whether GE could affect phencyclidine (PCP)-induced abnormal behavior in mice. Repeated treatment with PCP increased immobility time, while it decreased social interaction time and recognition memory. PCP-induced abnormal behaviors were significantly attenuated by GE, and these effects were comparable to those of 8-OH-DPAT, a 5-HT1A receptor agonist. Furthermore, GE-mediated effects were counteracted by WAY 100635, a 5-HT1A receptor antagonist. Our results suggest that the antipsychotic effects of GE are, at least in part, mediated via activation of 5-HT1A in mice.

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DO - 10.2174/157015911795017263

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Effects of Gastrodia elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice

Abstract

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All Science Journal Classification (ASJC) codes

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