Effects of haloperidol, sulpiride and SCH 23390 on passive avoidance learning in mice

Kenji Ichihara, Toshitaka Nabeshima, Tsutomu Kameyama

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The main purpose of the present study was to examine the effect of dopamine blockers on memory processes by means of a one-trial passive avoidance (PA) task with ddY mice. Haloperidol (0.025-0.4 mg/kg i.p.) did not affect the PA response when it was given before the training or retention test. Sulpiride (10-80 mg/kg i.p.) had different effects, depending on the doses employed: A lower dose (20 mg/kg) of sulpiride, which is thought to block presynaptic receptors, impaired the PA response but higher doses (40 and 80 mg/kg i.p.) did not affect it when sulpiride was given before the training or retention test. SCH 23390 (0.025-0.1 mg/kg i.p.) impaired the PA response only when it was given before the training. These results suggest that blocking of postsynaptic D-2 receptors does not impair memory processes but blocking of presynaptic D-2 receptors impairs both acquisition and retrieval stages of memory processes following an increase in dopamine release. The involvement of D-1 receptors in memory processes involved in the PA response may be essentially different from that of D-2 receptors, since the blocking of D1 receptors impaired only memory acquisition.

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalEuropean Journal of Pharmacology
Volume151
Issue number3
DOIs
Publication statusPublished - 14-07-1988
Externally publishedYes

Fingerprint

Avoidance Learning
Sulpiride
Haloperidol
Presynaptic Receptors
Dopamine Antagonists
Dopamine
SCH 23390
Retention (Psychology)

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

@article{6948dc36dd4944138ef83888ed044d46,
title = "Effects of haloperidol, sulpiride and SCH 23390 on passive avoidance learning in mice",
abstract = "The main purpose of the present study was to examine the effect of dopamine blockers on memory processes by means of a one-trial passive avoidance (PA) task with ddY mice. Haloperidol (0.025-0.4 mg/kg i.p.) did not affect the PA response when it was given before the training or retention test. Sulpiride (10-80 mg/kg i.p.) had different effects, depending on the doses employed: A lower dose (20 mg/kg) of sulpiride, which is thought to block presynaptic receptors, impaired the PA response but higher doses (40 and 80 mg/kg i.p.) did not affect it when sulpiride was given before the training or retention test. SCH 23390 (0.025-0.1 mg/kg i.p.) impaired the PA response only when it was given before the training. These results suggest that blocking of postsynaptic D-2 receptors does not impair memory processes but blocking of presynaptic D-2 receptors impairs both acquisition and retrieval stages of memory processes following an increase in dopamine release. The involvement of D-1 receptors in memory processes involved in the PA response may be essentially different from that of D-2 receptors, since the blocking of D1 receptors impaired only memory acquisition.",
author = "Kenji Ichihara and Toshitaka Nabeshima and Tsutomu Kameyama",
year = "1988",
month = "7",
day = "14",
doi = "10.1016/0014-2999(88)90540-7",
language = "English",
volume = "151",
pages = "435--442",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3",

}

Effects of haloperidol, sulpiride and SCH 23390 on passive avoidance learning in mice. / Ichihara, Kenji; Nabeshima, Toshitaka; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 151, No. 3, 14.07.1988, p. 435-442.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of haloperidol, sulpiride and SCH 23390 on passive avoidance learning in mice

AU - Ichihara, Kenji

AU - Nabeshima, Toshitaka

AU - Kameyama, Tsutomu

PY - 1988/7/14

Y1 - 1988/7/14

N2 - The main purpose of the present study was to examine the effect of dopamine blockers on memory processes by means of a one-trial passive avoidance (PA) task with ddY mice. Haloperidol (0.025-0.4 mg/kg i.p.) did not affect the PA response when it was given before the training or retention test. Sulpiride (10-80 mg/kg i.p.) had different effects, depending on the doses employed: A lower dose (20 mg/kg) of sulpiride, which is thought to block presynaptic receptors, impaired the PA response but higher doses (40 and 80 mg/kg i.p.) did not affect it when sulpiride was given before the training or retention test. SCH 23390 (0.025-0.1 mg/kg i.p.) impaired the PA response only when it was given before the training. These results suggest that blocking of postsynaptic D-2 receptors does not impair memory processes but blocking of presynaptic D-2 receptors impairs both acquisition and retrieval stages of memory processes following an increase in dopamine release. The involvement of D-1 receptors in memory processes involved in the PA response may be essentially different from that of D-2 receptors, since the blocking of D1 receptors impaired only memory acquisition.

AB - The main purpose of the present study was to examine the effect of dopamine blockers on memory processes by means of a one-trial passive avoidance (PA) task with ddY mice. Haloperidol (0.025-0.4 mg/kg i.p.) did not affect the PA response when it was given before the training or retention test. Sulpiride (10-80 mg/kg i.p.) had different effects, depending on the doses employed: A lower dose (20 mg/kg) of sulpiride, which is thought to block presynaptic receptors, impaired the PA response but higher doses (40 and 80 mg/kg i.p.) did not affect it when sulpiride was given before the training or retention test. SCH 23390 (0.025-0.1 mg/kg i.p.) impaired the PA response only when it was given before the training. These results suggest that blocking of postsynaptic D-2 receptors does not impair memory processes but blocking of presynaptic D-2 receptors impairs both acquisition and retrieval stages of memory processes following an increase in dopamine release. The involvement of D-1 receptors in memory processes involved in the PA response may be essentially different from that of D-2 receptors, since the blocking of D1 receptors impaired only memory acquisition.

UR - http://www.scopus.com/inward/record.url?scp=0023774687&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023774687&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(88)90540-7

DO - 10.1016/0014-2999(88)90540-7

M3 - Article

VL - 151

SP - 435

EP - 442

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 3

ER -