Effects of high temperature- and pressure-treated garlic on 1,2-dimethylhydrazine-induced premalignant lesions in the rat colorectum at the post-initiation stage

Takeshi Chihara, Kan Shimpo, Takaaki Kaneko, Hidehiko Beppu, Akiko Tomatsu, Takashi Higashiguchi, Shigeru Sonoda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined the effects of high temperature- and pressure-treated garlic (HTPG), which has enhanced anti-oxidative activity, on 1,2-dimethylhydrazine (DMH)-in-duced mucin-depleted foci (MDF), as premalignant lesions, in the rat colorectum at the post-initiation stage. Male F344 rats (5 weeks old) were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). Rats were fed basal diet or experimental diets containing 1% or 3% HTPG for 6weeks, starting 1week after the last injection of DMH. At sacrifice, the number of MDF in the 3% HTPG diet group was significantly lower than that in the basal diet group. In addition, we also studied the influence of 3% HTPG diet ingestion. Rats were fed basal diet or 3% HTPG diet under the above conditions without DMH treatment. The 3% HTPG diet did not affect most hematological and plasma biochemical parameters. These results, combined with our previous work (APJCP, 2009), suggest that HTPG may be useful as a health supplement.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume58
Issue number3
DOIs
Publication statusPublished - 08-09-2011

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1,2-dimethylhydrazine
1,2-Dimethylhydrazine
Garlic
garlic
lesions (animal)
Diet
Pressure
Temperature
rats
diet
temperature
mucins
Mucins
Inbred F344 Rats
experimental diets
antioxidant activity
ingestion
injection
Eating
Injections

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

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abstract = "We examined the effects of high temperature- and pressure-treated garlic (HTPG), which has enhanced anti-oxidative activity, on 1,2-dimethylhydrazine (DMH)-in-duced mucin-depleted foci (MDF), as premalignant lesions, in the rat colorectum at the post-initiation stage. Male F344 rats (5 weeks old) were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). Rats were fed basal diet or experimental diets containing 1{\%} or 3{\%} HTPG for 6weeks, starting 1week after the last injection of DMH. At sacrifice, the number of MDF in the 3{\%} HTPG diet group was significantly lower than that in the basal diet group. In addition, we also studied the influence of 3{\%} HTPG diet ingestion. Rats were fed basal diet or 3{\%} HTPG diet under the above conditions without DMH treatment. The 3{\%} HTPG diet did not affect most hematological and plasma biochemical parameters. These results, combined with our previous work (APJCP, 2009), suggest that HTPG may be useful as a health supplement.",
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Effects of high temperature- and pressure-treated garlic on 1,2-dimethylhydrazine-induced premalignant lesions in the rat colorectum at the post-initiation stage. / Chihara, Takeshi; Shimpo, Kan; Kaneko, Takaaki; Beppu, Hidehiko; Tomatsu, Akiko; Higashiguchi, Takashi; Sonoda, Shigeru.

In: Nippon Shokuhin Kagaku Kogaku Kaishi, Vol. 58, No. 3, 08.09.2011, p. 131-135.

Research output: Contribution to journalArticle

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AU - Sonoda, Shigeru

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