Effects of high temperature- and pressure-treated garlic on 1,2-dimethylhydrazine-induced premalignant lesions in the rat colorectum at the post-initiation stage

We examined the effects of high temperature- and pressure-treated garlic (HTPG), which has enhanced anti-oxidative activity, on 1,2-dimethylhydrazine (DMH)-in-duced mucin-depleted foci (MDF), as premalignant lesions, in the rat colorectum at the post-initiation stage. Male F344 rats (5 weeks old) were injected s.c. with DMH (40 mg/kg, once weekly for 2 weeks). Rats were fed basal diet or experimental diets containing 1% or 3% HTPG for 6weeks, starting 1week after the last injection of DMH. At sacrifice, the number of MDF in the 3% HTPG diet group was significantly lower than that in the basal diet group. In addition, we also studied the influence of 3% HTPG diet ingestion. Rats were fed basal diet or 3% HTPG diet under the above conditions without DMH treatment. The 3% HTPG diet did not affect most hematological and plasma biochemical parameters. These results, combined with our previous work (APJCP, 2009), suggest that HTPG may be useful as a health supplement.