Effects of histamine and hydroxyradical on collagen matrix contraction

T. Arisawa, Y. Tsukamoto, H. Goto, S. Hase, H. Endoh, N. Omiya, Y. Hirose, M. Hisatomi, E. Hamajima, T. Oiwa, S. Kanamori, S. Arisawa, M. Ohashi, J. Asai

Research output: Contribution to journalArticlepeer-review


We studied the effects of histamine and hydroxyradical on contraction of collagen matrix induced by the interactions between fibroblasts and collagen fibrils. Histamine had a stimulatory effect on the collagen gel contraction, and this stimulation could not be recognized by pyrilamine, an H1 antagonist. On the other hand, cimetidine, an H2 antagonist, had no effect on the histamine stimulated contraction of collagen gel. Collagen matrix contraction was significantly inhibited by influence of hydroxyradical, produced by ascorbate and copper ion, for more than 3 hours. These facts suggested that both histamine and hydroxyradical, mediators on the inflammation, might play important roles in granuration tissue contraction.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalTherapeutic Research
Issue numberSUPPL. 1
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Effects of histamine and hydroxyradical on collagen matrix contraction'. Together they form a unique fingerprint.

Cite this