Effects of histamine and hydroxyradical on collagen matrix contraction

T. Arisawa; Y. Tsukamoto; H. Goto; S. Hase; H. Endoh; N. Omiya; Y. Hirose; M. Hisatomi; E. Hamajima; T. Oiwa; S. Kanamori; S. Arisawa; M. Ohashi; J. Asai

Effects of histamine and hydroxyradical on collagen matrix contraction

T. Arisawa, Y. Tsukamoto, H. Goto, S. Hase, H. Endoh, N. Omiya, Y. Hirose, M. Hisatomi, E. Hamajima, T. Oiwa, S. Kanamori, S. Arisawa, M. Ohashi, J. Asai

Research output: Contribution to journal › Article › peer-review

Abstract

We studied the effects of histamine and hydroxyradical on contraction of collagen matrix induced by the interactions between fibroblasts and collagen fibrils. Histamine had a stimulatory effect on the collagen gel contraction, and this stimulation could not be recognized by pyrilamine, an H₁ antagonist. On the other hand, cimetidine, an H₂ antagonist, had no effect on the histamine stimulated contraction of collagen gel. Collagen matrix contraction was significantly inhibited by influence of hydroxyradical, produced by ascorbate and copper ion, for more than 3 hours. These facts suggested that both histamine and hydroxyradical, mediators on the inflammation, might play important roles in granuration tissue contraction.

Original language	English
Pages (from-to)	96-103
Number of pages	8
Journal	Therapeutic Research
Volume	15
Issue number	SUPPL. 1
Publication status	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

Cite this

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title = "Effects of histamine and hydroxyradical on collagen matrix contraction",

abstract = "We studied the effects of histamine and hydroxyradical on contraction of collagen matrix induced by the interactions between fibroblasts and collagen fibrils. Histamine had a stimulatory effect on the collagen gel contraction, and this stimulation could not be recognized by pyrilamine, an H1 antagonist. On the other hand, cimetidine, an H2 antagonist, had no effect on the histamine stimulated contraction of collagen gel. Collagen matrix contraction was significantly inhibited by influence of hydroxyradical, produced by ascorbate and copper ion, for more than 3 hours. These facts suggested that both histamine and hydroxyradical, mediators on the inflammation, might play important roles in granuration tissue contraction.",

author = "T. Arisawa and Y. Tsukamoto and H. Goto and S. Hase and H. Endoh and N. Omiya and Y. Hirose and M. Hisatomi and E. Hamajima and T. Oiwa and S. Kanamori and S. Arisawa and M. Ohashi and J. Asai",

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language = "English",

volume = "15",

pages = "96--103",

journal = "Therapeutic Research",

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T1 - Effects of histamine and hydroxyradical on collagen matrix contraction

AU - Arisawa, T.

AU - Tsukamoto, Y.

AU - Goto, H.

AU - Hase, S.

AU - Endoh, H.

AU - Omiya, N.

AU - Hirose, Y.

AU - Hisatomi, M.

AU - Hamajima, E.

AU - Oiwa, T.

AU - Kanamori, S.

AU - Arisawa, S.

AU - Ohashi, M.

AU - Asai, J.

PY - 1994

Y1 - 1994

N2 - We studied the effects of histamine and hydroxyradical on contraction of collagen matrix induced by the interactions between fibroblasts and collagen fibrils. Histamine had a stimulatory effect on the collagen gel contraction, and this stimulation could not be recognized by pyrilamine, an H1 antagonist. On the other hand, cimetidine, an H2 antagonist, had no effect on the histamine stimulated contraction of collagen gel. Collagen matrix contraction was significantly inhibited by influence of hydroxyradical, produced by ascorbate and copper ion, for more than 3 hours. These facts suggested that both histamine and hydroxyradical, mediators on the inflammation, might play important roles in granuration tissue contraction.

AB - We studied the effects of histamine and hydroxyradical on contraction of collagen matrix induced by the interactions between fibroblasts and collagen fibrils. Histamine had a stimulatory effect on the collagen gel contraction, and this stimulation could not be recognized by pyrilamine, an H1 antagonist. On the other hand, cimetidine, an H2 antagonist, had no effect on the histamine stimulated contraction of collagen gel. Collagen matrix contraction was significantly inhibited by influence of hydroxyradical, produced by ascorbate and copper ion, for more than 3 hours. These facts suggested that both histamine and hydroxyradical, mediators on the inflammation, might play important roles in granuration tissue contraction.

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AN - SCOPUS:0028268892

SN - 0289-8020

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JF - Therapeutic Research

IS - SUPPL. 1

ER -

Effects of histamine and hydroxyradical on collagen matrix contraction

Abstract

All Science Journal Classification (ASJC) codes

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