Effects of k-space orders on the time-intensity curves in dynamic contrast-enhanced magnetic resonance imaging of the breast based on simulation study

Yasuo Takatsu, Tsuyoshi Ueyama, Takahiro Iwasaki, Masaki Asahara, Michitaka Honda, Tosiaki Miyati

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study aims to investigate the influence of time-intensity curves (TICs) on the shapes using a dynamic contrast-enhanced magnetic resonance imaging (MRI) study depending on the Cartesian and radial orders for benign and cancerous breast tumors. Methods: Based on kinetic curve parameters, the signal intensities of six concentration gradients comprising two benign and four cancer models were used. The study aimed to construct a dynamic simulated image by creating a digital phantom image according to the following steps: (1) creating a simple numerical phantom, (2) setting the signal intensity in the contrast area, (3) creating the k-space in each time phase, (4) extracting data from k-space in each time phase, (5) filling in the k-space and adding data to the k-space assembly, and (6) creating a magnitude image. The TICs of Cartesian (centric and sequential) and radial (full-length [RFL] and half-length [RHL]) orders were created and sigmoid curve fitting was performed to compare these curves. Maximum slope (MS, s−1), width of the response (WOR, s), and primary signal response (PSR) were then calculated. Phase encode steps were set for 512 and 256. Results: MS was significantly decreased by radial order in the cancer model. No change was observed in WOR in Cartesian order, whereas RFL and RHL orders increased in the cancer models. PSR increased remarkably in the radial orders of cancer models. The difference in the fill slope in radial orders was remarkable when the TIC was steeper compared with when it was gentle, especially RHL. In WOR, both radial RFL and RHL were well matched except for the one benign model, and the shape of radial TIC was similar to sequential order as compared to centric order in 256 steps. Conclusion: The effects of Cartesian and radial orders on the patterns of TICs in a dynamic contrast-enhanced MRI study of benign and cancerous breast tumors were revealed. Interestingly, the TIC gradient of radial orders became gentler, particularly in the breast cancer MRI.

Original languageEnglish
Pages (from-to)85-96
Number of pages12
JournalMagnetic Resonance Imaging
Volume79
DOIs
Publication statusPublished - 06-2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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