Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D1and Serotonin 5-HT2A Receptor Binding

Seiichi Ishihara, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on specific [3H]SCH23390 binding to dopamine D1receptors and [3H]ketanserine binding to serotonin 5-HT2A receptors in the rat brain. Specific binding of both compounds was affected by aging. Long-term administration of KKT resulted in decreases in [3H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [3H]ketanserine binding to the caudate/putamen in young rats. These results suggest that the changes in dopamine D1 and serotonin 5-HT2A receptor binding may be involved in the central effects of KKT.

Original languageEnglish
Pages (from-to)1132-1134
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number8
DOIs
Publication statusPublished - 01-01-1994

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Receptor, Serotonin, 5-HT2A
Neurotransmitter Receptor
Chinese Traditional Medicine
Autoradiography
Dopamine
Brain
Putamen
Hippocampus
kamikihi-to
In Vitro Techniques
SCH 23390

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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title = "Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D1and Serotonin 5-HT2A Receptor Binding",
abstract = "Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on specific [3H]SCH23390 binding to dopamine D1receptors and [3H]ketanserine binding to serotonin 5-HT2A receptors in the rat brain. Specific binding of both compounds was affected by aging. Long-term administration of KKT resulted in decreases in [3H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [3H]ketanserine binding to the caudate/putamen in young rats. These results suggest that the changes in dopamine D1 and serotonin 5-HT2A receptor binding may be involved in the central effects of KKT.",
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T1 - Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography

T2 - Changes in Dopamine D1and Serotonin 5-HT2A Receptor Binding

AU - Ishihara, Seiichi

AU - Kameyama, Tsutomu

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

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