Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding

Tetsuo Hayashi, Kiyofumi Yamada, Takaaki Hasegawa, Toshitaka Nabeshima, Seiichi Ishihara, Tsutomu Kameyama, Tadaomi Morimasa, Takao Kaneyuki, Toshikiyo Shohmori

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.

Original languageEnglish
Pages (from-to)303-306
Number of pages4
JournalJapanese Journal of Pharmacology
Volume64
Issue number4
DOIs
Publication statusPublished - 01-01-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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