TY - JOUR
T1 - Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1)
T2 - Changes in the [3H]QNB Binding
AU - Hayashi, Tetsuo
AU - Yamada, Kiyofumi
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
AU - Ishihara, Seiichi
AU - Kameyama, Tsutomu
AU - Morimasa, Tadaomi
AU - Kaneyuki, Takao
AU - Shohmori, Toshikiyo
PY - 1994
Y1 - 1994
N2 - Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.
AB - Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.
UR - http://www.scopus.com/inward/record.url?scp=0028276737&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028276737&partnerID=8YFLogxK
U2 - 10.1254/jjp.64.303
DO - 10.1254/jjp.64.303
M3 - Article
C2 - 8057532
AN - SCOPUS:0028276737
SN - 0021-5198
VL - 64
SP - 303
EP - 306
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
IS - 4
ER -