Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding

Tetsuo Hayashi; Kiyofumi Yamada; Takaaki Hasegawa; Toshitaka Nabeshima; Seiichi Ishihara; Tsutomu Kameyama; Tadaomi Morimasa; Takao Kaneyuki; Toshikiyo Shohmori

doi:10.1254/jjp.64.303

Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding

Tetsuo Hayashi
, Kiyofumi Yamada
, Takaaki Hasegawa
, Toshitaka Nabeshima
, Seiichi Ishihara
, Tsutomu Kameyama
, Tadaomi Morimasa
, Takao Kaneyuki
, Toshikiyo Shohmori

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.

Original language	English
Pages (from-to)	303-306
Number of pages	4
Journal	Japanese Journal of Pharmacology
Volume	64
Issue number	4
DOIs	https://doi.org/10.1254/jjp.64.303
Publication status	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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Hayashi, T., Yamada, K., Hasegawa, T., Nabeshima, T., Ishihara, S., Kameyama, T., Morimasa, T., Kaneyuki, T., & Shohmori, T. (1994). Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding. Japanese Journal of Pharmacology, 64(4), 303-306. https://doi.org/10.1254/jjp.64.303

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title = "Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding",

abstract = "Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.",

author = "Tetsuo Hayashi and Kiyofumi Yamada and Takaaki Hasegawa and Toshitaka Nabeshima and Seiichi Ishihara and Tsutomu Kameyama and Tadaomi Morimasa and Takao Kaneyuki and Toshikiyo Shohmori",

year = "1994",

doi = "10.1254/jjp.64.303",

language = "English",

volume = "64",

pages = "303--306",

journal = "Japanese Journal of Pharmacology",

issn = "0021-5198",

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}

Hayashi, T, Yamada, K, Hasegawa, T, Nabeshima, T, Ishihara, S, Kameyama, T, Morimasa, T, Kaneyuki, T & Shohmori, T 1994, 'Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding', Japanese Journal of Pharmacology, vol. 64, no. 4, pp. 303-306. https://doi.org/10.1254/jjp.64.303

Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding. / Hayashi, Tetsuo; Yamada, Kiyofumi; Hasegawa, Takaaki et al.
In: Japanese Journal of Pharmacology, Vol. 64, No. 4, 1994, p. 303-306.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1)

T2 - Changes in the [3H]QNB Binding

AU - Hayashi, Tetsuo

AU - Yamada, Kiyofumi

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

AU - Ishihara, Seiichi

AU - Kameyama, Tsutomu

AU - Morimasa, Tadaomi

AU - Kaneyuki, Takao

AU - Shohmori, Toshikiyo

PY - 1994

Y1 - 1994

N2 - Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.

AB - Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on the specific binding of [3H]quinuclidinyl benzilate (QNB) and [3H]N-(l-[2-thienyl]cyclohexyl)-3,4-piperidine (TCP) in the rat brain. The Bmas but not the Kd values for [3H]QNB binding to the caudate/putamen and accumbens in aged rats were lower than those in young rats. The [3H]TCP binding was also decreased in aged rats compared with that in young rats. Long-term administration of KKT modulated the [3H]QNB binding in young but not aged rats.

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SN - 0021-5198

VL - 64

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JO - Japanese Journal of Pharmacology

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ER -

Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by In Vitro Autoradiography (1): Changes in the [3H]QNB Binding

Abstract

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