Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D1and Serotonin 5-HT2A Receptor Binding

Seiichi Ishihara; Tsutomu Kameyama; Takaaki Hasegawa; Toshitaka Nabeshima

doi:10.1248/bpb.17.1132

Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D₁and Serotonin 5-HT_2A Receptor Binding

Seiichi Ishihara
, Tsutomu Kameyama
, Takaaki Hasegawa
, Toshitaka Nabeshima

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on specific [³H]SCH23390 binding to dopamine D₁receptors and [³H]ketanserine binding to serotonin 5-HT_2A receptors in the rat brain. Specific binding of both compounds was affected by aging. Long-term administration of KKT resulted in decreases in [³H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [³H]ketanserine binding to the caudate/putamen in young rats. These results suggest that the changes in dopamine D₁ and serotonin 5-HT₂_A receptor binding may be involved in the central effects of KKT.

Original language	English
Pages (from-to)	1132-1134
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	17
Issue number	8
DOIs	https://doi.org/10.1248/bpb.17.1132
Publication status	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmaceutical Science

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Ishihara, S., Kameyama, T., Hasegawa, T., & Nabeshima, T. (1994). Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D₁and Serotonin 5-HT_2A Receptor Binding. Biological and Pharmaceutical Bulletin, 17(8), 1132-1134. https://doi.org/10.1248/bpb.17.1132

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abstract = "Using in vitro autoradiography, we investigated the effects of Kamikihito (KKT), a traditional Chinese medicine, on specific [3H]SCH23390 binding to dopamine D1receptors and [3H]ketanserine binding to serotonin 5-HT2A receptors in the rat brain. Specific binding of both compounds was affected by aging. Long-term administration of KKT resulted in decreases in [3H]SCH23390 binding to the cortex and hippocampus in aged rats, and in decreases in [3H]ketanserine binding to the caudate/putamen in young rats. These results suggest that the changes in dopamine D1 and serotonin 5-HT2A receptor binding may be involved in the central effects of KKT.",

author = "Seiichi Ishihara and Tsutomu Kameyama and Takaaki Hasegawa and Toshitaka Nabeshima",

year = "1994",

doi = "10.1248/bpb.17.1132",

language = "English",

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pages = "1132--1134",

journal = "Biological and Pharmaceutical Bulletin",

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Ishihara, S, Kameyama, T, Hasegawa, T & Nabeshima, T 1994, 'Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D₁and Serotonin 5-HT_2A Receptor Binding', Biological and Pharmaceutical Bulletin, vol. 17, no. 8, pp. 1132-1134. https://doi.org/10.1248/bpb.17.1132

Effects of Kamikihito, a Traditional Chinese Medicine, on Neurotransmitter Receptor Binding in the Aged Rat Brain Determined by in Vitro Autoradiography: Changes in Dopamine D₁and Serotonin 5-HT_2A Receptor Binding. / Ishihara, Seiichi; Kameyama, Tsutomu; Hasegawa, Takaaki et al.
In: Biological and Pharmaceutical Bulletin, Vol. 17, No. 8, 1994, p. 1132-1134.

Research output: Contribution to journal › Article › peer-review

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