Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1)

Chikako Shimizu, Yoshihisa Wakita, Takashi Inoue, Masanori Hiramitsu, Miki Okada, Yutaka Mitani, Shuichi Segawa, Youichi Tsuchiya, Toshitaka Nabeshima

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Abstract

Polyphenols have been examined for their beneficial effects on health, particularly in rodents, but their lifelong effects are unclear. Lemons (Citrus limon), containing lemon polyphenols (LPP), are widely consumed but the effects of LPP on aging are unknown. Therefore, we examined the effects of LPP on aging such as aging-related scores, locomotor activity, cognitive functions, and intestinal microbiome using senescence-accelerated mouse prone 1 (SAMP1) and senescence-accelerated resistant mouse 1 (SAMR1). All mice had ad libitum access to water (P1_water group, SAMR1) or 0.1% LPP (P1_LPP group). In the P1_LPP group, LPP intake prolonged the lifespan by approximately 3 weeks and delayed increases in aging-related scores (e.g., periophthalmic lesions) and locomotor atrophy. The P1_water group showed large changes in the intestinal microbiome structure, while the R1 and P1_LPP groups did not. The phylum Bacteroidetes/Firmicutes, which is associated with obesity, in the P1_water group was significantly lower and higher than that in the P1_LPP and R1 groups, respectively. Although the relative abundance of Lactobacillus significantly increased in both P1 groups with aging, the P1_LPP group showed a significantly lower increase than the P1_water group. Thus, lifelong intake of LPP may have anti-aging effects on both phenotypes and the intestinal environment.

Original languageEnglish
Article number3671
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 01-12-2019

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Polyphenols
Water
Gastrointestinal Microbiome
Bacteroidetes
Citrus
Lactobacillus
Locomotion
Cognition
Atrophy
Rodentia
Obesity
Phenotype

All Science Journal Classification (ASJC) codes

  • General

Cite this

Shimizu, Chikako ; Wakita, Yoshihisa ; Inoue, Takashi ; Hiramitsu, Masanori ; Okada, Miki ; Mitani, Yutaka ; Segawa, Shuichi ; Tsuchiya, Youichi ; Nabeshima, Toshitaka. / Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1). In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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Effects of lifelong intake of lemon polyphenols on aging and intestinal microbiome in the senescence-accelerated mouse prone 1 (SAMP1). / Shimizu, Chikako; Wakita, Yoshihisa; Inoue, Takashi; Hiramitsu, Masanori; Okada, Miki; Mitani, Yutaka; Segawa, Shuichi; Tsuchiya, Youichi; Nabeshima, Toshitaka.

In: Scientific Reports, Vol. 9, No. 1, 3671, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Shimizu, Chikako

AU - Wakita, Yoshihisa

AU - Inoue, Takashi

AU - Hiramitsu, Masanori

AU - Okada, Miki

AU - Mitani, Yutaka

AU - Segawa, Shuichi

AU - Tsuchiya, Youichi

AU - Nabeshima, Toshitaka

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