Abstract
We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.
| Original language | English |
|---|---|
| Pages (from-to) | 303-308 |
| Number of pages | 6 |
| Journal | Neuroscience Letters |
| Volume | 102 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 31-07-1989 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Effects of metaphit on phencyclidine and serotonin2 receptors. / Nabeshima, Toshitaka; Tohyama, Keiko; Noda, Akihiro; Maeda, Yohko; Hiramatsu, Masayuki; Harrer, Silvia M.; Kameyama, Tsutomu; Furukawa, Hiroshi; Jacobson, Arthur E.; Rice, Kenner C.
In: Neuroscience Letters, Vol. 102, No. 2-3, 31.07.1989, p. 303-308.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of metaphit on phencyclidine and serotonin2 receptors
AU - Nabeshima, Toshitaka
AU - Tohyama, Keiko
AU - Noda, Akihiro
AU - Maeda, Yohko
AU - Hiramatsu, Masayuki
AU - Harrer, Silvia M.
AU - Kameyama, Tsutomu
AU - Furukawa, Hiroshi
AU - Jacobson, Arthur E.
AU - Rice, Kenner C.
PY - 1989/7/31
Y1 - 1989/7/31
N2 - We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.
AB - We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.
UR - http://www.scopus.com/inward/record.url?scp=0024382686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024382686&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(89)90096-7
DO - 10.1016/0304-3940(89)90096-7
M3 - Article
C2 - 2554211
AN - SCOPUS:0024382686
VL - 102
SP - 303
EP - 308
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2-3
ER -