Effects of metaphit on phencyclidine and serotonin2 receptors

Toshitaka Nabeshima; Keiko Tohyama; Akihiro Noda; Yohko Maeda; Masayuki Hiramatsu; Silvia M. Harrer; Tsutomu Kameyama; Hiroshi Furukawa; Arthur E. Jacobson; Kenner C. Rice

doi:10.1016/0304-3940(89)90096-7

Effects of metaphit on phencyclidine and serotonin₂ receptors

Toshitaka Nabeshima, Keiko Tohyama, Akihiro Noda, Yohko Maeda, Masayuki Hiramatsu, Silvia M. Harrer, Tsutomu Kameyama, Hiroshi Furukawa, Arthur E. Jacobson, Kenner C. Rice

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin₂ (5-HT₂) receptors, and also whether metaphit decreases the capacity of 5-HT₂ receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT₂ receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT_1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT₂ receptors may have very similar binding sites.

Original language	English
Pages (from-to)	303-308
Number of pages	6
Journal	Neuroscience Letters
Volume	102
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(89)90096-7
Publication status	Published - 31-07-1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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Nabeshima, T., Tohyama, K., Noda, A., Maeda, Y., Hiramatsu, M., Harrer, S. M., Kameyama, T., Furukawa, H., Jacobson, A. E., & Rice, K. C. (1989). Effects of metaphit on phencyclidine and serotonin₂ receptors. Neuroscience Letters, 102(2-3), 303-308. https://doi.org/10.1016/0304-3940(89)90096-7

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title = "Effects of metaphit on phencyclidine and serotonin2 receptors",

abstract = "We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.",

author = "Toshitaka Nabeshima and Keiko Tohyama and Akihiro Noda and Yohko Maeda and Masayuki Hiramatsu and Harrer, {Silvia M.} and Tsutomu Kameyama and Hiroshi Furukawa and Jacobson, {Arthur E.} and Rice, {Kenner C.}",

year = "1989",

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doi = "10.1016/0304-3940(89)90096-7",

language = "English",

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journal = "Neuroscience Letters",

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T1 - Effects of metaphit on phencyclidine and serotonin2 receptors

AU - Nabeshima, Toshitaka

AU - Tohyama, Keiko

AU - Noda, Akihiro

AU - Maeda, Yohko

AU - Hiramatsu, Masayuki

AU - Harrer, Silvia M.

AU - Kameyama, Tsutomu

AU - Furukawa, Hiroshi

AU - Jacobson, Arthur E.

AU - Rice, Kenner C.

PY - 1989/7/31

Y1 - 1989/7/31

N2 - We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

AB - We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

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