Effects of metaphit on phencyclidine and serotonin2 receptors

Toshitaka Nabeshima, Keiko Tohyama, Akihiro Noda, Yohko Maeda, Masayuki Hiramatsu, Silvia M. Harrer, Tsutomu Kameyama, Hiroshi Furukawa, Arthur E. Jacobson, Kenner C. Rice

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Abstract

We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalNeuroscience Letters
Volume102
Issue number2-3
DOIs
Publication statusPublished - 31-07-1989

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Nabeshima, T., Tohyama, K., Noda, A., Maeda, Y., Hiramatsu, M., Harrer, S. M., Kameyama, T., Furukawa, H., Jacobson, A. E., & Rice, K. C. (1989). Effects of metaphit on phencyclidine and serotonin2 receptors. Neuroscience Letters, 102(2-3), 303-308. https://doi.org/10.1016/0304-3940(89)90096-7