Effects of metaphit on phencyclidine and serotonin2 receptors

Toshitaka Nabeshima; Keiko Tohyama; Akihiro Noda; Yohko Maeda; Masayuki Hiramatsu; Silvia M. Harrer; Tsutomu Kameyama; Hiroshi Furukawa; Arthur E. Jacobson; Kenner C. Rice

doi:10.1016/0304-3940(89)90096-7

Effects of metaphit on phencyclidine and serotonin₂ receptors

Toshitaka Nabeshima, Keiko Tohyama, Akihiro Noda, Yohko Maeda, Masayuki Hiramatsu, Silvia M. Harrer, Tsutomu Kameyama, Hiroshi Furukawa, Arthur E. Jacobson, Kenner C. Rice

Graduate School of Health Sciences

Research output: Contribution to journal › Article

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Abstract

We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin₂ (5-HT₂) receptors, and also whether metaphit decreases the capacity of 5-HT₂ receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT₂ receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT_1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT₂ receptors may have very similar binding sites.

Original language	English
Pages (from-to)	303-308
Number of pages	6
Journal	Neuroscience Letters
Volume	102
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(89)90096-7
Publication status	Published - 31-07-1989

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All Science Journal Classification (ASJC) codes

Neuroscience(all)

Cite this

Nabeshima, T., Tohyama, K., Noda, A., Maeda, Y., Hiramatsu, M., Harrer, S. M., Kameyama, T., Furukawa, H., Jacobson, A. E., & Rice, K. C. (1989). Effects of metaphit on phencyclidine and serotonin₂ receptors. Neuroscience Letters, 102(2-3), 303-308. https://doi.org/10.1016/0304-3940(89)90096-7

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title = "Effects of metaphit on phencyclidine and serotonin2 receptors",

abstract = "We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.",

author = "Toshitaka Nabeshima and Keiko Tohyama and Akihiro Noda and Yohko Maeda and Masayuki Hiramatsu and Harrer, {Silvia M.} and Tsutomu Kameyama and Hiroshi Furukawa and Jacobson, {Arthur E.} and Rice, {Kenner C.}",

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AU - Nabeshima, Toshitaka

AU - Tohyama, Keiko

AU - Noda, Akihiro

AU - Maeda, Yohko

AU - Hiramatsu, Masayuki

AU - Harrer, Silvia M.

AU - Kameyama, Tsutomu

AU - Furukawa, Hiroshi

AU - Jacobson, Arthur E.

AU - Rice, Kenner C.

PY - 1989/7/31

Y1 - 1989/7/31

N2 - We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

AB - We have investigated whether metaphit, a derivative of phencyclidine (PCP) which irreversibly binds to a population of PCP receptor sites in rat brain, blocks PCP-induced head-twitch response which is produced through serotonin2 (5-HT2) receptors, and also whether metaphit decreases the capacity of 5-HT2 receptors. Metaphit ( 1 μmol rat) had decreased the intensity of PCP-induced head-twitch response and had depleted both PCP and 5-HT2 receptors by 24 h after administration, but it failed to block 5-HT agonist 5-methoxy-N,N-dimethyltryptamine-induced 5-HT1A receptor-dependent behaviors. These results reconfirmed our hypothesis that PCP and 5-HT2 receptors may have very similar binding sites.

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10.1016/0304-3940(89)90096-7