Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia

Toshitaka Nabeshima, H. Morinaka, K. Kinbara, T. Kameyama

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.

Original languageEnglish
Pages (from-to)225-236
Number of pages12
JournalResearch Communications in Psychology, Psychiatry and Behavior
Issue number3
Publication statusPublished - 01-01-1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health


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