Abstract
The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.
Original language | English |
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Pages (from-to) | 225-236 |
Number of pages | 12 |
Journal | Research Communications in Psychology, Psychiatry and Behavior |
Volume | 14 |
Issue number | 3 |
Publication status | Published - 01-01-1989 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health