Abstract
The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.
| Original language | English |
|---|---|
| Pages (from-to) | 225-236 |
| Number of pages | 12 |
| Journal | Research Communications in Psychology, Psychiatry and Behavior |
| Volume | 14 |
| Issue number | 3 |
| Publication status | Published - 01-01-1989 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
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Nabeshima, T., Morinaka, H., Kinbara, K., & Kameyama, T. (1989). Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia. Research Communications in Psychology, Psychiatry and Behavior, 14(3), 225-236.