Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia

Toshitaka Nabeshima; H. Morinaka; K. Kinbara; T. Kameyama

Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia

Toshitaka Nabeshima, H. Morinaka, K. Kinbara, T. Kameyama

Research output: Contribution to journal › Article › peer-review

Abstract

The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.

Original language	English
Pages (from-to)	225-236
Number of pages	12
Journal	Research Communications in Psychology, Psychiatry and Behavior
Volume	14
Issue number	3
Publication status	Published - 01-01-1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health

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title = "Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia",

abstract = "The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.",

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AU - Nabeshima, Toshitaka

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AU - Kinbara, K.

AU - Kameyama, T.

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Y1 - 1989/1/1

N2 - The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.

AB - The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.

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Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia

Abstract

All Science Journal Classification (ASJC) codes

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