Abstract
The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.
| Original language | English |
|---|---|
| Pages (from-to) | 225-236 |
| Number of pages | 12 |
| Journal | Research Communications in Psychology, Psychiatry and Behavior |
| Volume | 14 |
| Issue number | 3 |
| Publication status | Published - 01-01-1989 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
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Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia. / Nabeshima, Toshitaka; Morinaka, H.; Kinbara, K.; Kameyama, T.
In: Research Communications in Psychology, Psychiatry and Behavior, Vol. 14, No. 3, 01.01.1989, p. 225-236.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of naftidrofuryl oxalate on the co-induced acute and delayed amnesia
AU - Nabeshima, Toshitaka
AU - Morinaka, H.
AU - Kinbara, K.
AU - Kameyama, T.
PY - 1989/1/1
Y1 - 1989/1/1
N2 - The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.
AB - The antiamnesic effects of naftidrofuryl oxalate (LS-121) on amnesia induced by carbon monoxide (CO) in mice were investigated using the passive avoidance task method and compared with that of Ca-hopantenate and physostigmine. In the mice exposed to CO before training, at the acquisition of memory and after the consolidation of memory, acute and delayed amnesia were induced. LS-121 ameliorated any amnesia in the above-mentioned; however, the effects of the reference drugs were inferior to those of LS-121. From these results, it appears that LS-121 has an antiamnesic effect of ischemic amnesia.
UR - http://www.scopus.com/inward/record.url?scp=0024432003&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024432003&partnerID=8YFLogxK
M3 - Article
VL - 14
SP - 225
EP - 236
JO - Research Communications in Psychology, Psychiatry and Behavior
JF - Research Communications in Psychology, Psychiatry and Behavior
SN - 0362-2428
IS - 3
ER -