Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani; K. Tohyama; K. Murase; S. Ishihara; T. Kameyama; T. Yamasaki; S. Hatanaka; H. Kojima; Y. Takasu; T. Nabeshima

doi:10.1007/BF01250792

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani, K. Tohyama, K. Murase, S. Ishihara, T. Kameyama, T. Yamasaki, S. Hatanaka, H. Kojima, Y. Takasu, T. Nabeshima

Emergency and General Internal Medicine

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

Original language	English
Pages (from-to)	103-111
Number of pages	9
Journal	Journal of Neural Transmission
Volume	90
Issue number	2
DOIs	https://doi.org/10.1007/BF01250792
Publication status	Published - 06-1992

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01250792

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title = "Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide",

abstract = "The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.",

author = "T. Shiotani and K. Tohyama and K. Murase and S. Ishihara and T. Kameyama and T. Yamasaki and S. Hatanaka and H. Kojima and Y. Takasu and T. Nabeshima",

year = "1992",

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doi = "10.1007/BF01250792",

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T1 - Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

AU - Shiotani, T.

AU - Tohyama, K.

AU - Murase, K.

AU - Ishihara, S.

AU - Kameyama, T.

AU - Yamasaki, T.

AU - Hatanaka, S.

AU - Kojima, H.

AU - Takasu, Y.

AU - Nabeshima, T.

PY - 1992/6

Y1 - 1992/6

N2 - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

AB - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

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JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 2

ER -

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

Abstract

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