Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani, K. Tohyama, K. Murase, S. Ishihara, T. Kameyama, T. Yamasaki, S. Hatanaka, H. Kojima, Y. Takasu, T. Nabeshima

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Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

Original languageEnglish
Pages (from-to)103-111
Number of pages9
JournalJournal of Neural Transmission
Volume90
Issue number2
DOIs
Publication statusPublished - 01-06-1992
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Shiotani, T., Tohyama, K., Murase, K., Ishihara, S., Kameyama, T., Yamasaki, T., Hatanaka, S., Kojima, H., Takasu, Y., & Nabeshima, T. (1992). Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide. Journal of Neural Transmission, 90(2), 103-111. https://doi.org/10.1007/BF01250792