Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani; K. Tohyama; K. Murase; S. Ishihara; T. Kameyama; T. Yamasaki; S. Hatanaka; H. Kojima; Y. Takasu; T. Nabeshima

doi:10.1007/BF01250792

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

T. Shiotani
, K. Tohyama
, K. Murase
, S. Ishihara
, T. Kameyama
, T. Yamasaki
, S. Hatanaka
, H. Kojima
, Y. Takasu
, T. Nabeshima

Emergency and General Internal Medicine

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

Original language	English
Pages (from-to)	103-111
Number of pages	9
Journal	Journal of Neural Transmission
Volume	90
Issue number	2
DOIs	https://doi.org/10.1007/BF01250792
Publication status	Published - 06-1992

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01250792

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title = "Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide",

abstract = "The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.",

author = "T. Shiotani and K. Tohyama and K. Murase and S. Ishihara and T. Kameyama and T. Yamasaki and S. Hatanaka and H. Kojima and Y. Takasu and T. Nabeshima",

year = "1992",

month = jun,

doi = "10.1007/BF01250792",

language = "English",

volume = "90",

pages = "103--111",

journal = "Journal of Neural Transmission",

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TY - JOUR

T1 - Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

AU - Shiotani, T.

AU - Tohyama, K.

AU - Murase, K.

AU - Ishihara, S.

AU - Kameyama, T.

AU - Yamasaki, T.

AU - Hatanaka, S.

AU - Kojima, H.

AU - Takasu, Y.

AU - Nabeshima, T.

PY - 1992/6

Y1 - 1992/6

N2 - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

AB - The effects of nefiracetam, [N-(2,6-dimethyl-phenyl)-2-(2-oxo-pyrrolidinyl)acetamide, DM-9384], a cyclic derivative of GABA, were investigated in the cycloheximide (CXM)-induced amnesia animal model using the passive avoidance task. Pre-training administration of DM-9384 attenuated the CXM-induced amnesia as indicated by prolongation of step-down latency. It protected against CXM-induced inhibition of choline acetyltransferase activity in the cerebral cortex. These results suggest that DM-9384 attenuates CXM-induced amnesia by interacting with AChergic neuronal system and enhancing protein synthesis in the brain.

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UR - https://www.scopus.com/pages/publications/0026564189#tab=citedBy

U2 - 10.1007/BF01250792

DO - 10.1007/BF01250792

M3 - Article

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AN - SCOPUS:0026564189

SN - 0300-9564

VL - 90

SP - 103

EP - 111

JO - Journal of Neural Transmission

JF - Journal of Neural Transmission

IS - 2

ER -

Effects of nefiracetam, DM-9384 on amnesia and decrease in cholineacetyltransferase activity induced by cycloheximide

Abstract

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