TY - JOUR
T1 - Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task
AU - Nabeshima, Toshitaka
AU - Nakayama, Shinobu
AU - Ichihara, Kenji
AU - Yamada, Kiyofumi
AU - Shiotani, Tadashi
AU - Hasegawa, Takaaki
N1 - Funding Information:
We are gratefutl o Daiichi PharmaceuticCaol . Ltd., and to the Hoffman-LaR ocheR esearchIn stitutefo r supplyingn efiracetaman d chlordiazepoxidree,s pectivelyT.h is studyw as supportedin, part,b y a Grant from the Japan ResearchF oundationfo r Clinical Pharmacology,b y a SRF Grant for BiomedicaRl esearcha ndby a Grant-in-Aid for GerontologicaSlc ienceR esearch(9 1A-2406f)r om the Ministry of Health and Welfare,J apan and a Grant-in-Aidfo r Science Research(N o. 05454148f)r om the Ministry of EducationS, cience and Culture,J apan.
PY - 1994/4/1
Y1 - 1994/4/1
N2 - We investigated the effects of nefiracetam (DM-9384), a pyrrolidone derivative, on chlordiazepoxide-, apomorphine-, and methamphetamine-induced impairment of latent learning in a water finding test in mice. Pretreatment with nefiracetam reversed the inhibitory effects of chlordiazepoxide and apomorphine, but not those of methamphetamine, on latent learning. The ameliorative effects of nefiracetam on apomorphine-induced, but not chlordiazepoxide-induced impairment of latent learning were antagonized by scopolamine. These results provide further evidence that nefiracetam has anti-amnesic effects. Further, it is suggested that the cholinergic neuronal system may be involved in the ameliorative effects exerted by nefiracetam on apomorphine-induced impairment of latent learning.
AB - We investigated the effects of nefiracetam (DM-9384), a pyrrolidone derivative, on chlordiazepoxide-, apomorphine-, and methamphetamine-induced impairment of latent learning in a water finding test in mice. Pretreatment with nefiracetam reversed the inhibitory effects of chlordiazepoxide and apomorphine, but not those of methamphetamine, on latent learning. The ameliorative effects of nefiracetam on apomorphine-induced, but not chlordiazepoxide-induced impairment of latent learning were antagonized by scopolamine. These results provide further evidence that nefiracetam has anti-amnesic effects. Further, it is suggested that the cholinergic neuronal system may be involved in the ameliorative effects exerted by nefiracetam on apomorphine-induced impairment of latent learning.
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U2 - 10.1016/0014-2999(94)90082-5
DO - 10.1016/0014-2999(94)90082-5
M3 - Article
C2 - 8026554
AN - SCOPUS:0028207467
SN - 0014-2999
VL - 255
SP - 57
EP - 65
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-3
ER -