Effects of nefiracetam on drug-induced impairment of latent learning in mice in a water finding task

Toshitaka Nabeshima, Shinobu Nakayama, Kenji Ichihara, Kiyofumi Yamada, Tadashi Shiotani, Takaaki Hasegawa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We investigated the effects of nefiracetam (DM-9384), a pyrrolidone derivative, on chlordiazepoxide-, apomorphine-, and methamphetamine-induced impairment of latent learning in a water finding test in mice. Pretreatment with nefiracetam reversed the inhibitory effects of chlordiazepoxide and apomorphine, but not those of methamphetamine, on latent learning. The ameliorative effects of nefiracetam on apomorphine-induced, but not chlordiazepoxide-induced impairment of latent learning were antagonized by scopolamine. These results provide further evidence that nefiracetam has anti-amnesic effects. Further, it is suggested that the cholinergic neuronal system may be involved in the ameliorative effects exerted by nefiracetam on apomorphine-induced impairment of latent learning.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalEuropean Journal of Pharmacology
Volume255
Issue number1-3
DOIs
Publication statusPublished - 01-04-1994

All Science Journal Classification (ASJC) codes

  • Pharmacology

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