TY - JOUR
T1 - Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions
AU - Ogawa, Shin ichi
AU - Nabeshima, Toshitaka
AU - Kameyama, Tsutomu
AU - Nabeshima, Toshitaka
AU - Hayashi, Kyozo
PY - 1993
Y1 - 1993
N2 - Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.
AB - Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.
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U2 - 10.1254/jjp.61.141
DO - 10.1254/jjp.61.141
M3 - Article
C2 - 8459651
AN - SCOPUS:0027471293
SN - 0021-5198
VL - 61
SP - 141
EP - 144
JO - Journal of Pharmacological Sciences
JF - Journal of Pharmacological Sciences
IS - 2
ER -