Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions

Shin ichi Ogawa, Toshitaka Nabeshima, Tsutomu Kameyama, Toshitaka Nabeshima, Kyozo Hayashi

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15 Citations (Scopus)


Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalJournal of Pharmacological Sciences
Issue number2
Publication statusPublished - 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology


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