Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions

Shin ichi Ogawa, Toshitaka Nabeshima, Tsutomu Kameyama, Toshitaka Nabeshima, Kyozo Hayashi

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13 Citations (Scopus)

Abstract

Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalThe Japanese Journal of Pharmacology
Volume61
Issue number2
DOIs
Publication statusPublished - 01-01-1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Ogawa, S. I., Nabeshima, T., Kameyama, T., Nabeshima, T., & Hayashi, K. (1993). Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions. The Japanese Journal of Pharmacology, 61(2), 141-144. https://doi.org/10.1254/jjp.61.141