Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions

Shin ichi Ogawa, Toshitaka Nabeshima, Tsutomu Kameyama, Toshitaka Nabeshima, Kyozo Hayashi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalThe Japanese Journal of Pharmacology
Volume61
Issue number2
DOIs
Publication statusPublished - 01-01-1993
Externally publishedYes

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Nerve Growth Factor
Amnesia
Choline O-Acetyltransferase
Parietal Lobe
Cholinergic Neurons
Basal Forebrain
Water

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Ogawa, Shin ichi ; Nabeshima, Toshitaka ; Kameyama, Tsutomu ; Nabeshima, Toshitaka ; Hayashi, Kyozo. / Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions. In: The Japanese Journal of Pharmacology. 1993 ; Vol. 61, No. 2. pp. 141-144.
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Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions. / Ogawa, Shin ichi; Nabeshima, Toshitaka; Kameyama, Tsutomu; Nabeshima, Toshitaka; Hayashi, Kyozo.

In: The Japanese Journal of Pharmacology, Vol. 61, No. 2, 01.01.1993, p. 141-144.

Research output: Contribution to journalArticle

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