Effects of oral administration of chlordecone and mirex on brain biogenic amines in mice

K. Fujimori, Toshitaka Nabeshima, I. K. Ho, H. M. Mehendale

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and the 5-HT metabolite, 5-hydroxyindole acetic acid (5-HIAA) were determined in brains of mice after daily oral administration of 10, 25 or 50 mg/kg of chlordecone or mirex until mortality occurred. Significant decreases in whole brain and striatal DA levels were observed in chlordecone-treated mice exhibiting tremors. Mirex had no effect at the 3 doses tested. In mice treated with chlordecone or mirex, the 5-HT levels were elevated only in animals exhibiting severe tremors or diarrhea, respectively. NE levels were not altered by chlordecone or mirex. These results suggest that chlordecone-induced neurotoxicity may be due in part to a decrease in the inhibitory state of dopamine neurons.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalNeuroToxicology
Volume3
Issue number2
Publication statusPublished - 01-12-1982
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Toxicology

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