Effects of osmolality changes in nebulizar solutions on nasal mucosa

Mayumi Komori, Masato Miwa, Toshiko Mamiya, Yuka Kondo, Akihiko Takasu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The effects of osmolarity changes in nebulizer solutions on nasal mucosa was not known clearly. We measured nasal airway resistance, total nasal volume, weight of nasal drop and nasal mucociliay clearance by saccharin granule technique during the aerosol administration. The contents of nebulizer solutions were distilled water, physiological saline solution and 10% saline solution. Mucociliary clearance were improved in each concentration of solutions. Total nasal volume, nasal airway resistance and weight of nasal drop increased after inhalation of hypertonic saline. These results suggest osmolarity changes of nebulizer solutions affect mucociliary clearance and nasal mucosal swelling.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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