Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice

T. Nabeshima; M. Hiramatsu; H. Furukawa; T. Kameyama

doi:10.1016/0028-3908(85)90016-4

Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice

T. Nabeshima, M. Hiramatsu, H. Furukawa, T. Kameyama

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5 Citations (Scopus)

Abstract

The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.

Original language	English
Pages (from-to)	805-809
Number of pages	5
Journal	Neuropharmacology
Volume	24
Issue number	8
DOIs	https://doi.org/10.1016/0028-3908(85)90016-4
Publication status	Published - 08-1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/0028-3908(85)90016-4

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@article{9c60203d24414c52a9b9638a4b223d72,

title = "Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice",

abstract = "The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.",

author = "T. Nabeshima and M. Hiramatsu and H. Furukawa and T. Kameyama",

note = "Funding Information: This study was supported in part by grants-in-aid from The Ishida Foundation (#59-2921,The Mochida Memorial Foundation for Medical and Pharmaceutical Research (#59-2-7) and The Research Foundation for Pharmaceutical Scienses (159-I-12). We thank Miss. Kyoko Mizuno for her technical supports and Mr. William Petruschak for English revision of the manuscript.",

year = "1985",

month = aug,

doi = "10.1016/0028-3908(85)90016-4",

language = "English",

volume = "24",

pages = "805--809",

journal = "Neuropharmacology",

issn = "0028-3908",

publisher = "Elsevier Ltd",

number = "8",

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T1 - Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice

AU - Nabeshima, T.

AU - Hiramatsu, M.

AU - Furukawa, H.

AU - Kameyama, T.

N1 - Funding Information: This study was supported in part by grants-in-aid from The Ishida Foundation (#59-2921,The Mochida Memorial Foundation for Medical and Pharmaceutical Research (#59-2-7) and The Research Foundation for Pharmaceutical Scienses (159-I-12). We thank Miss. Kyoko Mizuno for her technical supports and Mr. William Petruschak for English revision of the manuscript.

PY - 1985/8

Y1 - 1985/8

N2 - The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.

AB - The study investigated the interaction between phencyclidine (PCP) and morphine in affecting the levels of met-enkephalin, dopamine, DOPAC and HVA in mice. Morphine 5 mg/kg alone and PCP 10 mg/kg alone failed to change the levels of met-enkephalin in the midbrain and striatum. However, PCP in combination with morphine produced an increase in met-enkephalin levels and a decrease in HVA levels. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. These results suggest that PCP may change the function in dopaminergic and enkephalinergic neuronal systems in the midbrain and/or striatum.

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DO - 10.1016/0028-3908(85)90016-4

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JO - Neuropharmacology

JF - Neuropharmacology

IS - 8

ER -

Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice

Abstract

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