Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-α expression in rats with aspirin-induced gastric mucosal injury

Y. Naito, T. Yoshikawa, N. Yagi, K. Matsuyama, N. Yoshida, K. Seto, T. Yoneta

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

We examined the roles of lipid peroxidation, neutrophil accumulation, and inflammatory cytokines in the protective effect of polaprezinc against aspirin-induced gastric mucosal injury in rats. The intragastric administration of acidified aspirin induced hyperemia and hemorrhagic erosions in rat stomachs. The increase in the total gastric erosive area after aspirin administration was significantly inhibited in a dose-dependent manner by treatment with polaprezinc. The increases in thiobarbituric acid-reactive substances and tissue-associated myeloperoxidase activity 3 hr after aspirin administration were significantly inhibited by pretreatment with polaprezinc. The gastric concentration of TNF-α increased after aspirin administration, and the increase was also inhibited in a dose-dependent manner by treatment with polaprezinc. The peak expression of TNF-α mRNA 1 hr after aspirin administration was inhibited by 30 mg/kg of polaprezinc. Based on these data, the beneficial effects of polaprezinc on aspirin-induced gastric mucosal injury may be attributed to its antioxidative and antiinflammatory properties.

Original languageEnglish
Pages (from-to)845-851
Number of pages7
JournalDigestive Diseases and Sciences
Volume46
Issue number4
DOIs
Publication statusPublished - 07-05-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

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