Effects of polaprezinc (Z-103) on chronic ulcer model induced by Fe2+-ascorbic acid in rats

T. Yoneta, H. Morita, Y. Hori, K. Seto, H. Yamada, T. Takemasa, Y. Ikeda, Y. Naito, T. Yoshikawa

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Abstract

In order to determine the role of antioxidative effects of polaprezinc (Z-103) in the mechanism of its anti-ulcer effects, a new chronic ulcer model was produced using Fe2+-ascorbic acid, a free radical generation system, and experiments were conducted to determine characteristics of this model and effects of Z-103 on it. Chronic ulcers were produced by locally injecting 0.4 M Fe2+-ascorbic acid under the serosa in the anterior wall of the glandular stomach. In this model, 3 mg/kg of Z-103 significantly reduced the ulcer area on the 10th and 14th days, and its effects were dose-dependent on the 14th day. In this model, 100 mg/kg of cetraxate HCl and 10 μg/kg of 16, 16-dimethylprostaglandin E2 had almost no effects. However, 200 mg/kg of cimetidine, an H2-antagonist, markedly reduced the ulcer area on the 14th day. On the 11th day, significant increases in TBA-reactive substances and myeloperoxidase activity were observed in ulcerative areas compared to nonulcerative areas. Z-103 (1-10 mg/kg) dose-dependently decreased them, and its effects were significant at 10 mg/kg. While L-carnosine, a related substance of Z-103, had no effect, zinc sulfate and a combination of zinc sulfate and L-carnosine reduced the ulcer area on the 14th day at a dose epuivalent to 3 mg/kg of Z-103. From these findings, free radicals and acid secretion were thought to be involved in the development of chronic ulcer in this model. Z-103 showed marked efficacy in this model, and its effects were thought to be mainly attributable to its antioxidative effects and promoting action of the wound healing of this compound.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalTherapeutic Research
Volume15
Issue number11
Publication statusPublished - 01-01-1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Yoneta, T., Morita, H., Hori, Y., Seto, K., Yamada, H., Takemasa, T., Ikeda, Y., Naito, Y., & Yoshikawa, T. (1994). Effects of polaprezinc (Z-103) on chronic ulcer model induced by Fe2+-ascorbic acid in rats. Therapeutic Research, 15(11), 393-399.