Effects of polaprezinc (Z-103) on various acute experimental models of gastric and duodenal lesions in rats. Comparison with the other anti-ulcer drugs II

T. Yoneta, H. Morita, Y. Hori, K. Seto, R. Hosokawa, Y. Ikeda

Research output: Contribution to journalArticle

Abstract

We investigated the anti-ulcer effects of polaprezinc (Z-103) and sucralfate using several acute experimental models of gastric and duodenal lesions in rats. Z-103 prevented the development of gastric and duodenal lesions induced by water immersion stress, acidified ethanol, indomethacin, compound 48/80 and mepirizole. However, Z-103 was not influenced on experimental models of gastric lesions related to acid secretion, such as aspirin in pylorus-ligated and Shay ulcers. Sucralfate also prevented the development of gastric and duodenal lesions on several experimental models except for compound 48/80. The efficacy of Z-103 was superior to sucralfate, without aspirin in pylorus-ligated and Shay ulcers. These results indicate that Z-103 strongly prevents the development of gastric and duodenal lesions without affecting acid secretion. Therefore, Z-103 may be useful for the treatment of gastric and duodenal ulcers in clinical therapy.

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalTherapeutic Research
Volume15
Issue number10
Publication statusPublished - 01-01-1994

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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