TY - JOUR
T1 - Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population
AU - Ito, Yoshinori
AU - Suzuki, Koji
AU - Imai, Hideo
AU - Sakamoto, Hiroshi
AU - Nakano, Hiroshi
N1 - Funding Information:
This study was supported in part by a Grant-in Aid from the Ministry of Education, Science and Culture for Monbusho Cancer Research Program and Foundation of Nagoya Preventive Medical Institute. The authors are grateful to all participants and the health care staff in Y-town in Hokkaido (director: Professor Emeritus K. Aoki). We also thank Professor S. Kikuchi, Aichi Medical University, for his helpful advice.
PY - 2001/2/26
Y1 - 2001/2/26
N2 - In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.
AB - In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.
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U2 - 10.1016/S0304-3835(00)00686-8
DO - 10.1016/S0304-3835(00)00686-8
M3 - Article
C2 - 11165751
AN - SCOPUS:0035952365
SN - 0304-3835
VL - 163
SP - 171
EP - 178
JO - Cancer Letters
JF - Cancer Letters
IS - 2
ER -
