Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population

Yoshinori Ito, Koji Suzuki, Hideo Imai, Hiroshi Sakamoto, Hiroshi Nakano

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In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalCancer Letters
Issue number2
Publication statusPublished - 26-02-2001


All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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