Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population

Yoshinori Ito, Koji Suzuki, Hideo Imai, Hiroshi Sakamoto, Hiroshi Nakano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalCancer Letters
Volume163
Issue number2
DOIs
Publication statusPublished - 26-02-2001

Fingerprint

Atrophic Gastritis
Unsaturated Fatty Acids
Docosahexaenoic Acids
Population
Pepsinogen C
Serum
Pepsinogen A
alpha-Linolenic Acid
Omega-3 Fatty Acids
Gastritis
Odds Ratio
Incidence
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ito, Yoshinori ; Suzuki, Koji ; Imai, Hideo ; Sakamoto, Hiroshi ; Nakano, Hiroshi. / Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. In: Cancer Letters. 2001 ; Vol. 163, No. 2. pp. 171-178.
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Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. / Ito, Yoshinori; Suzuki, Koji; Imai, Hideo; Sakamoto, Hiroshi; Nakano, Hiroshi.

In: Cancer Letters, Vol. 163, No. 2, 26.02.2001, p. 171-178.

Research output: Contribution to journalArticle

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