Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population

Yoshinori Ito; Koji Suzuki; Hideo Imai; Hiroshi Sakamoto; Hiroshi Nakano

doi:10.1016/S0304-3835(00)00686-8

Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population

Yoshinori Ito, Koji Suzuki, Hideo Imai, Hiroshi Sakamoto, Hiroshi Nakano

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.

Original language	English
Pages (from-to)	171-178
Number of pages	8
Journal	Cancer Letters
Volume	163
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(00)00686-8
Publication status	Published - 26-02-2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(00)00686-8

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title = "Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population",

abstract = "In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95\% C.I.: 1.10-4.39) and 0.34 (95\% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.",

keywords = "Atrophic gastritis, Docosahexaenoic acid, Helicobacter pylori, γ-Linolenic acid",

author = "Yoshinori Ito and Koji Suzuki and Hideo Imai and Hiroshi Sakamoto and Hiroshi Nakano",

note = "Funding Information: This study was supported in part by a Grant-in Aid from the Ministry of Education, Science and Culture for Monbusho Cancer Research Program and Foundation of Nagoya Preventive Medical Institute. The authors are grateful to all participants and the health care staff in Y-town in Hokkaido (director: Professor Emeritus K. Aoki). We also thank Professor S. Kikuchi, Aichi Medical University, for his helpful advice.",

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doi = "10.1016/S0304-3835(00)00686-8",

language = "English",

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T1 - Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population

AU - Ito, Yoshinori

AU - Suzuki, Koji

AU - Imai, Hideo

AU - Sakamoto, Hiroshi

AU - Nakano, Hiroshi

N1 - Funding Information: This study was supported in part by a Grant-in Aid from the Ministry of Education, Science and Culture for Monbusho Cancer Research Program and Foundation of Nagoya Preventive Medical Institute. The authors are grateful to all participants and the health care staff in Y-town in Hokkaido (director: Professor Emeritus K. Aoki). We also thank Professor S. Kikuchi, Aichi Medical University, for his helpful advice.

PY - 2001/2/26

Y1 - 2001/2/26

N2 - In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.

AB - In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of γ-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.

KW - Atrophic gastritis

KW - Docosahexaenoic acid

KW - Helicobacter pylori

KW - γ-Linolenic acid

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AN - SCOPUS:0035952365

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JO - Cancer Letters

JF - Cancer Letters

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ER -

Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population

Abstract

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