TY - JOUR
T1 - Effects of polyunsaturated fatty acids on periprocedural myocardial infarction after elective percutaneous coronary intervention
AU - Suzuki, Akihiro
AU - Ando, Hirohiko
AU - Takashima, Hiroaki
AU - Kumagai, Soichiro
AU - Kurita, Akiyoshi
AU - Waseda, Katsuhisa
AU - Suzuki, Yasushi
AU - Mizuno, Tomofumi
AU - Harada, Ken
AU - Uetani, Tadayuki
AU - Takahashi, Hiroshi
AU - Yoshikawa, Daiji
AU - Ishii, Hideki
AU - Murohara, Toyoaki
AU - Amano, Tetsuya
N1 - Publisher Copyright:
© 2014, EuroPCR. All rights reserved.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Aims: The aim of this study was to address the association of lipid profiles with periprocedural myocardial infarction (pMI) after elective percutaneous coronary intervention (PCI). Methods and results: Of the 302 consecutive patients who received elective PCI at the Chubu Rosai Hospital, Nagoya, Japan between June 2009 and December 2010, data from 231 native coronary lesions were analysed. Various biomarkers including serum troponin T (TnT), eicosapentaenoic acid (EPA), arachidonic acid (AA), and lowdensity lipoprotein (LDL) and highdensity lipoprotein (HDL) cholesterol were measured at baseline and at 18 hrs after PCI. pMI was defined as a postprocedural increase of TnT >3 times above the upper normal limit. Patients with pMI had significantly lower EPA/AA (0.25 [0.190.28] vs. 0.45 [0.210.62], p<0.001) and higher LDL/HDL cholesterol (3.00±1.05 vs. 2.36±0.90, p=0.008) than patients without pMI. On multivariate logistic analysis, EPA/AA per 0.1 increase (hazard ratio [HR] 0.62, 95% CI: 0.430.88, p=0.007), LDL/HDL (HR 1.92, 95% CI: 1.153.19, p=0.012), stented length (HR 1.40, 95% CI: 1.071.83, p=0.015), and the presence of unstable angina pectoris (UAP) (HR 8.89, 95% CI: 2.8327.9, p<0.001) were significantly and independently associated with the incidence of pMI. Conclusions: EPA/AA and LDL/HDL were significantly associated with pMI after PCI, creating the possibility of a new therapeutic target of pMI.
AB - Aims: The aim of this study was to address the association of lipid profiles with periprocedural myocardial infarction (pMI) after elective percutaneous coronary intervention (PCI). Methods and results: Of the 302 consecutive patients who received elective PCI at the Chubu Rosai Hospital, Nagoya, Japan between June 2009 and December 2010, data from 231 native coronary lesions were analysed. Various biomarkers including serum troponin T (TnT), eicosapentaenoic acid (EPA), arachidonic acid (AA), and lowdensity lipoprotein (LDL) and highdensity lipoprotein (HDL) cholesterol were measured at baseline and at 18 hrs after PCI. pMI was defined as a postprocedural increase of TnT >3 times above the upper normal limit. Patients with pMI had significantly lower EPA/AA (0.25 [0.190.28] vs. 0.45 [0.210.62], p<0.001) and higher LDL/HDL cholesterol (3.00±1.05 vs. 2.36±0.90, p=0.008) than patients without pMI. On multivariate logistic analysis, EPA/AA per 0.1 increase (hazard ratio [HR] 0.62, 95% CI: 0.430.88, p=0.007), LDL/HDL (HR 1.92, 95% CI: 1.153.19, p=0.012), stented length (HR 1.40, 95% CI: 1.071.83, p=0.015), and the presence of unstable angina pectoris (UAP) (HR 8.89, 95% CI: 2.8327.9, p<0.001) were significantly and independently associated with the incidence of pMI. Conclusions: EPA/AA and LDL/HDL were significantly associated with pMI after PCI, creating the possibility of a new therapeutic target of pMI.
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U2 - 10.4244/EIJV10I7A138
DO - 10.4244/EIJV10I7A138
M3 - Article
C2 - 25415148
AN - SCOPUS:84911468154
SN - 1774-024X
VL - 10
SP - 792
EP - 798
JO - EuroIntervention
JF - EuroIntervention
IS - 7
ER -