TY - JOUR
T1 - Effects of pranlukast hydrate on serum eosinophil cationic protein levels in patients with adult bronchial asthma
AU - Horiguchi, Takahiko
AU - Tachikawa, Soichi
AU - Kasahara, Junichi
AU - Doi, Masashi
AU - Shiga, Mamoru
PY - 1999
Y1 - 1999
N2 - Pranlukast hydrate (CAS 103177-37-3, ONO-1078) was administered to 20 patients with bronchial asthma, and examined the effects of this agent on serum eosinophil cationic protein (ECP) levels and peripheral blood eosinophil counts. The mean serum ECP level in the group comprised of patients with bronchial asthma was significantly higher than that in the control group comprised of healthy adults. In responders in whom improvement in asthmatic symptoms was observed, serum ECP levels were significantly decreased compared to the pretreatment values 4 weeks after commencement of pranlukast hydrate administration. However, there were no changes in non- responders. There was no correlation between serum ECP level and peripheral blood eosinophil count before administration of pranlukast hydrate. However, there was a correlation 4 weeks after administration was started. Iris suggested that pranlukast hydrate inhibits eosinophilic activity in patients with bronchial asthma.
AB - Pranlukast hydrate (CAS 103177-37-3, ONO-1078) was administered to 20 patients with bronchial asthma, and examined the effects of this agent on serum eosinophil cationic protein (ECP) levels and peripheral blood eosinophil counts. The mean serum ECP level in the group comprised of patients with bronchial asthma was significantly higher than that in the control group comprised of healthy adults. In responders in whom improvement in asthmatic symptoms was observed, serum ECP levels were significantly decreased compared to the pretreatment values 4 weeks after commencement of pranlukast hydrate administration. However, there were no changes in non- responders. There was no correlation between serum ECP level and peripheral blood eosinophil count before administration of pranlukast hydrate. However, there was a correlation 4 weeks after administration was started. Iris suggested that pranlukast hydrate inhibits eosinophilic activity in patients with bronchial asthma.
UR - http://www.scopus.com/inward/record.url?scp=0032894980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032894980&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1300355
DO - 10.1055/s-0031-1300355
M3 - Article
C2 - 10028377
AN - SCOPUS:0032894980
SN - 0004-4172
VL - 49
SP - 35
EP - 37
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
IS - 1
ER -