Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring

Toshitaka Nabeshima; Masayuki Hiramatsu; Kazumasa Yamaguchi; Masami Kasugai; Kimie Ishizaki; Kazuaki Kawashima; Kaname Itoh; Shin Ichi Ogawa; Akira Katoh; Hiroshi Furukawa; Tsutomu Kameyama

doi:10.1248/bpb1978.11.816

Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring

Toshitaka Nabeshima, Masayuki Hiramatsu, Kazumasa Yamaguchi, Masami Kasugai, Kimie Ishizaki, Kazuaki Kawashima, Kaname Itoh, Shin Ichi Ogawa, Akira Katoh, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The effects of prenatal administration of phencyclidine (PCP) on the learning and memory processes of rat offspring were investigated at doses below the level for producing malformations. The offspring prenatally treated with PCP (10 or 20 mg/kg) on days 7 to 17, as well as on days 7 to 21 of gestation, showed disruption of the acquisition of passive avoidance response and pole-climbing avoidance response at the ages of 4 and 7 weeks, respectively. The brain weight of the offspring prenatally treated with PCP was significantly decreased. These results suggest that prenatal PCP administration impairs learning and memory processes of passive and active avoidance tasks and that more attention should be given to the developmental toxicity of PCP.

Original language	English
Pages (from-to)	816-823
Number of pages	8
Journal	Journal of Pharmacobio-Dynamics
Volume	11
Issue number	12
DOIs	https://doi.org/10.1248/bpb1978.11.816
Publication status	Published - 01-02-1988
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology

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10.1248/bpb1978.11.816

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title = "Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring",

abstract = "The effects of prenatal administration of phencyclidine (PCP) on the learning and memory processes of rat offspring were investigated at doses below the level for producing malformations. The offspring prenatally treated with PCP (10 or 20 mg/kg) on days 7 to 17, as well as on days 7 to 21 of gestation, showed disruption of the acquisition of passive avoidance response and pole-climbing avoidance response at the ages of 4 and 7 weeks, respectively. The brain weight of the offspring prenatally treated with PCP was significantly decreased. These results suggest that prenatal PCP administration impairs learning and memory processes of passive and active avoidance tasks and that more attention should be given to the developmental toxicity of PCP.",

author = "Toshitaka Nabeshima and Masayuki Hiramatsu and Kazumasa Yamaguchi and Masami Kasugai and Kimie Ishizaki and Kazuaki Kawashima and Kaname Itoh and Ogawa, {Shin Ichi} and Akira Katoh and Hiroshi Furukawa and Tsutomu Kameyama",

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T1 - Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring

AU - Nabeshima, Toshitaka

AU - Hiramatsu, Masayuki

AU - Yamaguchi, Kazumasa

AU - Kasugai, Masami

AU - Ishizaki, Kimie

AU - Kawashima, Kazuaki

AU - Itoh, Kaname

AU - Ogawa, Shin Ichi

AU - Katoh, Akira

AU - Furukawa, Hiroshi

AU - Kameyama, Tsutomu

PY - 1988/2/1

Y1 - 1988/2/1

N2 - The effects of prenatal administration of phencyclidine (PCP) on the learning and memory processes of rat offspring were investigated at doses below the level for producing malformations. The offspring prenatally treated with PCP (10 or 20 mg/kg) on days 7 to 17, as well as on days 7 to 21 of gestation, showed disruption of the acquisition of passive avoidance response and pole-climbing avoidance response at the ages of 4 and 7 weeks, respectively. The brain weight of the offspring prenatally treated with PCP was significantly decreased. These results suggest that prenatal PCP administration impairs learning and memory processes of passive and active avoidance tasks and that more attention should be given to the developmental toxicity of PCP.

AB - The effects of prenatal administration of phencyclidine (PCP) on the learning and memory processes of rat offspring were investigated at doses below the level for producing malformations. The offspring prenatally treated with PCP (10 or 20 mg/kg) on days 7 to 17, as well as on days 7 to 21 of gestation, showed disruption of the acquisition of passive avoidance response and pole-climbing avoidance response at the ages of 4 and 7 weeks, respectively. The brain weight of the offspring prenatally treated with PCP was significantly decreased. These results suggest that prenatal PCP administration impairs learning and memory processes of passive and active avoidance tasks and that more attention should be given to the developmental toxicity of PCP.

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Effects of Prenatal Administration of Phencyclidine on the Learning and Memory Processes of Rat Offspring

Abstract

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