Effects of prenatal and perinatal administration of phencyclidine on the behavioral development of rat offspring

Toshitaka Nabeshima, Kazumasa Yamaguchi, Masayuki Hiramatsu, Kazuhiro Ishikawa, Hiroshi Furukawa, Tsutomu Kameyama

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of prenatal and perinatal administration of a nonteratogenic dose of phencyclidine (PCP) on the behavioral development of Sprague-Dawley rats were examined. In the offspring prenatally treated with PCP (10 mg/kg) between days 7 and 17 of gestation, a decrease in maternal body weight in the gestation period, a decrease in fetal body weight and body length, a decrease in viability of offsprings, and a decrease in the body weights of the offspring in the nursing period were observed. Furthermore, PCP pups had difficulty performing the rota-rod task at 4 weeks and exhibited a decrease in sensitivity to challenged PCP at 5 weeks (female). In the offspring prenatally treated with PCP between days 7 and 21 of gestation, a decrease in the body weights of dams, fetuses and offspring, and a decrease in the viability of offsprings were observed. PCP pups showed an increase in the score for head-twitch response (male), a delay in the development of ambulation, negative geotaxis (male), bar holding and rope-descending behavior (female). However, the PCP administration during prenatal (between days 17 and 21 of gestation) and nursing periods showed only a decrease in viability and body weight of offspring, and a delay in the development of the separation of eyelids. These results suggest that more attention should be given to the developmental toxicity of PCP.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume28
Issue number3
DOIs
Publication statusPublished - 01-01-1987
Externally publishedYes

Fingerprint

Phencyclidine
Nursing
Rats
Body Weight
Pregnancy
Dams
Toxicity
Fetal Weight
Eyelids
Walking
Sprague Dawley Rats
Fetus
Head
Mothers

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Nabeshima, Toshitaka ; Yamaguchi, Kazumasa ; Hiramatsu, Masayuki ; Ishikawa, Kazuhiro ; Furukawa, Hiroshi ; Kameyama, Tsutomu. / Effects of prenatal and perinatal administration of phencyclidine on the behavioral development of rat offspring. In: Pharmacology, Biochemistry and Behavior. 1987 ; Vol. 28, No. 3. pp. 411-418.
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Effects of prenatal and perinatal administration of phencyclidine on the behavioral development of rat offspring. / Nabeshima, Toshitaka; Yamaguchi, Kazumasa; Hiramatsu, Masayuki; Ishikawa, Kazuhiro; Furukawa, Hiroshi; Kameyama, Tsutomu.

In: Pharmacology, Biochemistry and Behavior, Vol. 28, No. 3, 01.01.1987, p. 411-418.

Research output: Contribution to journalArticle

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