Abstract
Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 99-102 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 150 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 05-02-1993 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
Cite this
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Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats. / Fuji, Kazuyuki; Hiramatsu, Masayuki; Hayashi, Saori; Kameyama, Tsutomu; Nabeshima, Toshitaka.
In: Neuroscience Letters, Vol. 150, No. 1, 05.02.1993, p. 99-102.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of propentofylline, a NGF synthesis stimulator, on alterations in muscarinic cholinergic receptors induced by basal forebrain lesion in rats
AU - Fuji, Kazuyuki
AU - Hiramatsu, Masayuki
AU - Hayashi, Saori
AU - Kameyama, Tsutomu
AU - Nabeshima, Toshitaka
PY - 1993/2/5
Y1 - 1993/2/5
N2 - Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction.
AB - Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=0027208902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027208902&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(93)90117-4
DO - 10.1016/0304-3940(93)90117-4
M3 - Article
C2 - 8469410
AN - SCOPUS:0027208902
VL - 150
SP - 99
EP - 102
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -