Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins

Hiroshi Ageta, Akihiko Kato, Yugo Fukazawa, Kaoru Inokuchi, Hiroyuki Sugiyama

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The Vesl-1S/Homer-1a proteins are upregulated during seizure and long-term potentiation, but are rapidly degraded by ubiquitin-proteasome systems under normal conditions. We examined the distribution of Vesl-1S proteins in cultured hippocampal neurons. Application of proteasome inhibitors caused accumulation of Vesl-1S immunoreactivity in the neurons which showed a punctate distribution in the cortical regions of the cells, and these puncta were found to be juxtaposed with synaptophysin, a presynaptic, synapse-specific protein. These results suggest that Vesl-1S protein is synaptically targeted.

Original languageEnglish
Pages (from-to)186-189
Number of pages4
JournalMolecular Brain Research
Volume97
Issue number2
DOIs
Publication statusPublished - 30-12-2001

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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