TY - JOUR
T1 - Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins
AU - Ageta, Hiroshi
AU - Kato, Akihiko
AU - Fukazawa, Yugo
AU - Inokuchi, Kaoru
AU - Sugiyama, Hiroyuki
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2001/12/30
Y1 - 2001/12/30
N2 - The Vesl-1S/Homer-1a proteins are upregulated during seizure and long-term potentiation, but are rapidly degraded by ubiquitin-proteasome systems under normal conditions. We examined the distribution of Vesl-1S proteins in cultured hippocampal neurons. Application of proteasome inhibitors caused accumulation of Vesl-1S immunoreactivity in the neurons which showed a punctate distribution in the cortical regions of the cells, and these puncta were found to be juxtaposed with synaptophysin, a presynaptic, synapse-specific protein. These results suggest that Vesl-1S protein is synaptically targeted.
AB - The Vesl-1S/Homer-1a proteins are upregulated during seizure and long-term potentiation, but are rapidly degraded by ubiquitin-proteasome systems under normal conditions. We examined the distribution of Vesl-1S proteins in cultured hippocampal neurons. Application of proteasome inhibitors caused accumulation of Vesl-1S immunoreactivity in the neurons which showed a punctate distribution in the cortical regions of the cells, and these puncta were found to be juxtaposed with synaptophysin, a presynaptic, synapse-specific protein. These results suggest that Vesl-1S protein is synaptically targeted.
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U2 - 10.1016/S0169-328X(01)00303-5
DO - 10.1016/S0169-328X(01)00303-5
M3 - Article
C2 - 11750075
AN - SCOPUS:0035977412
SN - 0169-328X
VL - 97
SP - 186
EP - 189
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -