Effects Of Repeated Administration Of Imipramine On Mice: Neurochemical And Behavioral Studies

Soichiro Nomura, Nobuyuki Ukei, Jun Shimizu, Shiroh Sakaida, Tsuneyuki Nakazawa

Research output: Contribution to journalArticlepeer-review

Abstract

Imipramine (about 30 mg/kg a day) was given to mice orally for 14 days. β-adrenergic receptor binding in the cerebral cortex, the Forced Swimming Test and the Open Field Test was examined sequentially. β-receptor binding decreased and the wheel turning behavior in the Forced Swimming Test increased with repeated dose of imipramine. The both parameters returned to the original level relatively rapidly after the termination of the drug. The locomotor activity in the Open Field Test did not change through the all experimental days. The relationship between behavioral and neurochemical changes was discussed.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
Journalthe keio journal of medicine
Volume33
Issue number3
DOIs
Publication statusPublished - 01-1984

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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