Effects Of Repeated Administration Of Imipramine On Mice: Neurochemical And Behavioral Studies

Soichiro Nomura; Nobuyuki Ukei; Jun Shimizu; Shiroh Sakaida; Tsuneyuki Nakazawa

doi:10.2302/kjm.33.137

Effects Of Repeated Administration Of Imipramine On Mice: Neurochemical And Behavioral Studies

Soichiro Nomura, Nobuyuki Ukei, Jun Shimizu, Shiroh Sakaida, Tsuneyuki Nakazawa

Faculty of Nursing

Research output: Contribution to journal › Article › peer-review

Abstract

Imipramine (about 30 mg/kg a day) was given to mice orally for 14 days. β-adrenergic receptor binding in the cerebral cortex, the Forced Swimming Test and the Open Field Test was examined sequentially. β-receptor binding decreased and the wheel turning behavior in the Forced Swimming Test increased with repeated dose of imipramine. The both parameters returned to the original level relatively rapidly after the termination of the drug. The locomotor activity in the Open Field Test did not change through the all experimental days. The relationship between behavioral and neurochemical changes was discussed.

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	the keio journal of medicine
Volume	33
Issue number	3
DOIs	https://doi.org/10.2302/kjm.33.137
Publication status	Published - 01-1984

All Science Journal Classification (ASJC) codes

General Medicine

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abstract = "Imipramine (about 30 mg/kg a day) was given to mice orally for 14 days. β-adrenergic receptor binding in the cerebral cortex, the Forced Swimming Test and the Open Field Test was examined sequentially. β-receptor binding decreased and the wheel turning behavior in the Forced Swimming Test increased with repeated dose of imipramine. The both parameters returned to the original level relatively rapidly after the termination of the drug. The locomotor activity in the Open Field Test did not change through the all experimental days. The relationship between behavioral and neurochemical changes was discussed.",

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AU - Nakazawa, Tsuneyuki

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AB - Imipramine (about 30 mg/kg a day) was given to mice orally for 14 days. β-adrenergic receptor binding in the cerebral cortex, the Forced Swimming Test and the Open Field Test was examined sequentially. β-receptor binding decreased and the wheel turning behavior in the Forced Swimming Test increased with repeated dose of imipramine. The both parameters returned to the original level relatively rapidly after the termination of the drug. The locomotor activity in the Open Field Test did not change through the all experimental days. The relationship between behavioral and neurochemical changes was discussed.

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Effects Of Repeated Administration Of Imipramine On Mice: Neurochemical And Behavioral Studies

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