Abstract
It has been reported that pretreatment with (-)-nicotine prevents glutamate- and amyloid beta protein (Aβ)-induced cytotoxicity in vitro. However, few studies on the neuroprotective effects of (-)-nicotine in vivo have been reported. We examined whether repeated administration of (-)-nicotine exhibits neuroprotective effects in AF64A-treated rats. (-)-Nicotine (0.1 and 0.2mg/kg, s.c.) was administered once a day for 28 days. On day 14, AF64A (2.5nmol/side) was injected bilaterally into the hippocampus. Intrahippocampal injection of AF64A showed severe impairment of learning and memory in rats in the water maze and passive avoidance tests. Repeated administration of (-)-nicotine (0.1 and 0.2mg/kg, s.c.) did not reverse the impairment of memory induced by AF64A in the water maze test. Interestingly, the (-)-nicotine (0.1 and 0.2mg/kg, s.c.)-treated group showed weak impairment of learning and memory after AF64A treatment compared to the (AF64A + saline)-treated group in the passive avoidance test. These results suggested that (-)-nicotine may have neuroprotective effects against the neurotoxicity induced by AF64A.
| Original language | English |
|---|---|
| Pages (from-to) | 361-375 |
| Number of pages | 15 |
| Journal | Journal of Neural Transmission |
| Volume | 109 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 06-04-2002 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats. / Hiramatsu, M.; Yamatsu, T.; Kameyama, T.; Nabeshima, Toshitaka.
In: Journal of Neural Transmission, Vol. 109, No. 3, 06.04.2002, p. 361-375.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of repeated administration of (-)-nicotine on AF64A-induced learning and memory impairment in rats
AU - Hiramatsu, M.
AU - Yamatsu, T.
AU - Kameyama, T.
AU - Nabeshima, Toshitaka
PY - 2002/4/6
Y1 - 2002/4/6
N2 - It has been reported that pretreatment with (-)-nicotine prevents glutamate- and amyloid beta protein (Aβ)-induced cytotoxicity in vitro. However, few studies on the neuroprotective effects of (-)-nicotine in vivo have been reported. We examined whether repeated administration of (-)-nicotine exhibits neuroprotective effects in AF64A-treated rats. (-)-Nicotine (0.1 and 0.2mg/kg, s.c.) was administered once a day for 28 days. On day 14, AF64A (2.5nmol/side) was injected bilaterally into the hippocampus. Intrahippocampal injection of AF64A showed severe impairment of learning and memory in rats in the water maze and passive avoidance tests. Repeated administration of (-)-nicotine (0.1 and 0.2mg/kg, s.c.) did not reverse the impairment of memory induced by AF64A in the water maze test. Interestingly, the (-)-nicotine (0.1 and 0.2mg/kg, s.c.)-treated group showed weak impairment of learning and memory after AF64A treatment compared to the (AF64A + saline)-treated group in the passive avoidance test. These results suggested that (-)-nicotine may have neuroprotective effects against the neurotoxicity induced by AF64A.
AB - It has been reported that pretreatment with (-)-nicotine prevents glutamate- and amyloid beta protein (Aβ)-induced cytotoxicity in vitro. However, few studies on the neuroprotective effects of (-)-nicotine in vivo have been reported. We examined whether repeated administration of (-)-nicotine exhibits neuroprotective effects in AF64A-treated rats. (-)-Nicotine (0.1 and 0.2mg/kg, s.c.) was administered once a day for 28 days. On day 14, AF64A (2.5nmol/side) was injected bilaterally into the hippocampus. Intrahippocampal injection of AF64A showed severe impairment of learning and memory in rats in the water maze and passive avoidance tests. Repeated administration of (-)-nicotine (0.1 and 0.2mg/kg, s.c.) did not reverse the impairment of memory induced by AF64A in the water maze test. Interestingly, the (-)-nicotine (0.1 and 0.2mg/kg, s.c.)-treated group showed weak impairment of learning and memory after AF64A treatment compared to the (AF64A + saline)-treated group in the passive avoidance test. These results suggested that (-)-nicotine may have neuroprotective effects against the neurotoxicity induced by AF64A.
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U2 - 10.1007/s007020200029
DO - 10.1007/s007020200029
M3 - Article
VL - 109
SP - 361
EP - 375
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
SN - 0300-9564
IS - 3
ER -