TY - JOUR
T1 - Effects of roxithromycin on adhesion molecules expressed on endothelial cells of the dermal microvasculature
AU - Akamatsu, H.
AU - Yamawaki, M.
AU - Horio, T.
PY - 2001
Y1 - 2001
N2 - The objective of the study was to investigate the pharmacological action of roxithromycin, an oral macrolide antibiotic. The effects of roxithromycin on the cytokine-induced expression of endothelial leukocyte adhesion molecule (E-selectin) and intracellular adhesion molecule (ICAM)-1 on endothelial cells of the dermal microvasculature were investigated in vitro using flow cytometry. Roxithromycin at a concentration of 0.5 μg/ml, which is lower than the therapeutic plasma concentration (ordinary daily dose, 150 - 300 mg), significantly inhibited the expression of E-selectin and ICAM-1 on endothelial cells of the dermal microvasculature induced by tumour necrosis factor-α. We conclude that roxithromycin may exert its antiinflammatory action by inhibition of the in vivo expression of adhesion molecules on dermal microvascular endothelial cells.
AB - The objective of the study was to investigate the pharmacological action of roxithromycin, an oral macrolide antibiotic. The effects of roxithromycin on the cytokine-induced expression of endothelial leukocyte adhesion molecule (E-selectin) and intracellular adhesion molecule (ICAM)-1 on endothelial cells of the dermal microvasculature were investigated in vitro using flow cytometry. Roxithromycin at a concentration of 0.5 μg/ml, which is lower than the therapeutic plasma concentration (ordinary daily dose, 150 - 300 mg), significantly inhibited the expression of E-selectin and ICAM-1 on endothelial cells of the dermal microvasculature induced by tumour necrosis factor-α. We conclude that roxithromycin may exert its antiinflammatory action by inhibition of the in vivo expression of adhesion molecules on dermal microvascular endothelial cells.
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U2 - 10.1177/147323000102900609
DO - 10.1177/147323000102900609
M3 - Article
C2 - 11803737
AN - SCOPUS:0035679501
SN - 0300-0605
VL - 29
SP - 523
EP - 527
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 6
ER -