Effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by propionibacterium acnes

Hirohiko Akamatsu, T. Tomita, T. Horio

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Background: The macrolide antibiotic roxithromycin is effective against acne associated with inflammation, but the mechanism by which this is achieved has not been clarified. Objective: We studied the effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes in vitro. Results: Roxithromycin significantly inhibited the production of lipase and neutrophil chemotactic factor by P. acnes at a concentration one eighth of the MIC, at which the growth curve of P. acnes is not affected. Conclusion: One mechanism of the effectiveness of roxithromycin in acne therapy is thought to be the inhibition of bacterial lipase and neutrophil chemotactic factor production by P. acnes.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalDermatology
Volume204
Issue number4
DOIs
Publication statusPublished - 02-07-2002

All Science Journal Classification (ASJC) codes

  • Dermatology

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