Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain

Kazuhiro Ishikawa, Atsumi Nitta, Hiroyuki Mizoguchi, Akihiro Mohri, Rina Murai, Yoshiaki Miyamoto, Yukihiro Noda, Kiyoyuki Kitaichi, Kiyofumi Yamada, Toshitaka Nabeshima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The rearrangement of neural networks associated with the behavioural sensitization and tolerance induced by psychostimulants is poorly understood. We have investigated the effects of repeated administration of methamphetamine (chronic MAP), which induces behavioural sensitization, or morphine (chronic morphine), which induces tolerance to its antinociceptive effect, on the mRNA levels of neural network-related genes in the rat brain. A gene of special interest was that for neuroglycan C (NGC), a neural tissue-specific transmembrane chondroitin sulphate proteoglycan. Single MAP (acute MAP) administration significantly decreased NGC mRNA levels in the frontal cortex, ventral tegmental area (VTA), and amygdala compared to vehicle-treated groups. Repeated MAP (chronic MAP) administration significantly increased NGC mRNA levels in the frontal cortex, nucleus accumbens (NAc), striatum, hippocampus, VTA, and amygdala compared to acute MAP treatment. Single morphine (acute morphine) administration significantly increased NGC mRNA levels in the NAc, striatum, hippocampus, VTA, and amygdala compared to vehicle-treated groups. Chronic morphine administration significantly decreased NGC mRNA levels in the NAc, striatum, VTA, and amygdala compared to acute treatment. In addition, the NGC protein level in the NAc was increased after chronic MAP and acute morphine treatment. Dopamine and opioid receptor antagonists attenuated the effect of MAP and morphine respectively on NGC mRNA levels. These results suggest that the sensitization to MAP is associated with up-regulation of NGC gene expression, while the tolerance to the morphine-induced analgesic effect is associated with the down-regulation of NGC gene expression.

Original languageEnglish
Pages (from-to)407-415
Number of pages9
JournalInternational Journal of Neuropsychopharmacology
Volume9
Issue number4
DOIs
Publication statusPublished - 01-08-2006

Fingerprint

Methamphetamine
Morphine
Gene Expression
Ventral Tegmental Area
Nucleus Accumbens
Brain
Amygdala
Messenger RNA
Frontal Lobe
Hippocampus
Chondroitin Sulfate Proteoglycans
Narcotic Antagonists
Dopamine Antagonists
Gene Regulatory Networks
Protein C
Analgesics
Up-Regulation
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Ishikawa, Kazuhiro ; Nitta, Atsumi ; Mizoguchi, Hiroyuki ; Mohri, Akihiro ; Murai, Rina ; Miyamoto, Yoshiaki ; Noda, Yukihiro ; Kitaichi, Kiyoyuki ; Yamada, Kiyofumi ; Nabeshima, Toshitaka. / Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain. In: International Journal of Neuropsychopharmacology. 2006 ; Vol. 9, No. 4. pp. 407-415.
@article{d1ccb63ebf1f4d618658d4668a84dc70,
title = "Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain",
abstract = "The rearrangement of neural networks associated with the behavioural sensitization and tolerance induced by psychostimulants is poorly understood. We have investigated the effects of repeated administration of methamphetamine (chronic MAP), which induces behavioural sensitization, or morphine (chronic morphine), which induces tolerance to its antinociceptive effect, on the mRNA levels of neural network-related genes in the rat brain. A gene of special interest was that for neuroglycan C (NGC), a neural tissue-specific transmembrane chondroitin sulphate proteoglycan. Single MAP (acute MAP) administration significantly decreased NGC mRNA levels in the frontal cortex, ventral tegmental area (VTA), and amygdala compared to vehicle-treated groups. Repeated MAP (chronic MAP) administration significantly increased NGC mRNA levels in the frontal cortex, nucleus accumbens (NAc), striatum, hippocampus, VTA, and amygdala compared to acute MAP treatment. Single morphine (acute morphine) administration significantly increased NGC mRNA levels in the NAc, striatum, hippocampus, VTA, and amygdala compared to vehicle-treated groups. Chronic morphine administration significantly decreased NGC mRNA levels in the NAc, striatum, VTA, and amygdala compared to acute treatment. In addition, the NGC protein level in the NAc was increased after chronic MAP and acute morphine treatment. Dopamine and opioid receptor antagonists attenuated the effect of MAP and morphine respectively on NGC mRNA levels. These results suggest that the sensitization to MAP is associated with up-regulation of NGC gene expression, while the tolerance to the morphine-induced analgesic effect is associated with the down-regulation of NGC gene expression.",
author = "Kazuhiro Ishikawa and Atsumi Nitta and Hiroyuki Mizoguchi and Akihiro Mohri and Rina Murai and Yoshiaki Miyamoto and Yukihiro Noda and Kiyoyuki Kitaichi and Kiyofumi Yamada and Toshitaka Nabeshima",
year = "2006",
month = "8",
day = "1",
doi = "10.1017/S1461145705005870",
language = "English",
volume = "9",
pages = "407--415",
journal = "International Journal of Neuropsychopharmacology",
issn = "1461-1457",
publisher = "Cambridge University Press",
number = "4",

}

Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain. / Ishikawa, Kazuhiro; Nitta, Atsumi; Mizoguchi, Hiroyuki; Mohri, Akihiro; Murai, Rina; Miyamoto, Yoshiaki; Noda, Yukihiro; Kitaichi, Kiyoyuki; Yamada, Kiyofumi; Nabeshima, Toshitaka.

In: International Journal of Neuropsychopharmacology, Vol. 9, No. 4, 01.08.2006, p. 407-415.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain

AU - Ishikawa, Kazuhiro

AU - Nitta, Atsumi

AU - Mizoguchi, Hiroyuki

AU - Mohri, Akihiro

AU - Murai, Rina

AU - Miyamoto, Yoshiaki

AU - Noda, Yukihiro

AU - Kitaichi, Kiyoyuki

AU - Yamada, Kiyofumi

AU - Nabeshima, Toshitaka

PY - 2006/8/1

Y1 - 2006/8/1

N2 - The rearrangement of neural networks associated with the behavioural sensitization and tolerance induced by psychostimulants is poorly understood. We have investigated the effects of repeated administration of methamphetamine (chronic MAP), which induces behavioural sensitization, or morphine (chronic morphine), which induces tolerance to its antinociceptive effect, on the mRNA levels of neural network-related genes in the rat brain. A gene of special interest was that for neuroglycan C (NGC), a neural tissue-specific transmembrane chondroitin sulphate proteoglycan. Single MAP (acute MAP) administration significantly decreased NGC mRNA levels in the frontal cortex, ventral tegmental area (VTA), and amygdala compared to vehicle-treated groups. Repeated MAP (chronic MAP) administration significantly increased NGC mRNA levels in the frontal cortex, nucleus accumbens (NAc), striatum, hippocampus, VTA, and amygdala compared to acute MAP treatment. Single morphine (acute morphine) administration significantly increased NGC mRNA levels in the NAc, striatum, hippocampus, VTA, and amygdala compared to vehicle-treated groups. Chronic morphine administration significantly decreased NGC mRNA levels in the NAc, striatum, VTA, and amygdala compared to acute treatment. In addition, the NGC protein level in the NAc was increased after chronic MAP and acute morphine treatment. Dopamine and opioid receptor antagonists attenuated the effect of MAP and morphine respectively on NGC mRNA levels. These results suggest that the sensitization to MAP is associated with up-regulation of NGC gene expression, while the tolerance to the morphine-induced analgesic effect is associated with the down-regulation of NGC gene expression.

AB - The rearrangement of neural networks associated with the behavioural sensitization and tolerance induced by psychostimulants is poorly understood. We have investigated the effects of repeated administration of methamphetamine (chronic MAP), which induces behavioural sensitization, or morphine (chronic morphine), which induces tolerance to its antinociceptive effect, on the mRNA levels of neural network-related genes in the rat brain. A gene of special interest was that for neuroglycan C (NGC), a neural tissue-specific transmembrane chondroitin sulphate proteoglycan. Single MAP (acute MAP) administration significantly decreased NGC mRNA levels in the frontal cortex, ventral tegmental area (VTA), and amygdala compared to vehicle-treated groups. Repeated MAP (chronic MAP) administration significantly increased NGC mRNA levels in the frontal cortex, nucleus accumbens (NAc), striatum, hippocampus, VTA, and amygdala compared to acute MAP treatment. Single morphine (acute morphine) administration significantly increased NGC mRNA levels in the NAc, striatum, hippocampus, VTA, and amygdala compared to vehicle-treated groups. Chronic morphine administration significantly decreased NGC mRNA levels in the NAc, striatum, VTA, and amygdala compared to acute treatment. In addition, the NGC protein level in the NAc was increased after chronic MAP and acute morphine treatment. Dopamine and opioid receptor antagonists attenuated the effect of MAP and morphine respectively on NGC mRNA levels. These results suggest that the sensitization to MAP is associated with up-regulation of NGC gene expression, while the tolerance to the morphine-induced analgesic effect is associated with the down-regulation of NGC gene expression.

UR - http://www.scopus.com/inward/record.url?scp=33745543706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745543706&partnerID=8YFLogxK

U2 - 10.1017/S1461145705005870

DO - 10.1017/S1461145705005870

M3 - Article

C2 - 16146580

AN - SCOPUS:33745543706

VL - 9

SP - 407

EP - 415

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - 4

ER -