Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene

T. Nabeshima, A. Itoh, K. Kobayashi, S. Morita, T. Mizuguchi, H. Sawada, A. Nitta, T. Hasegawa, K. Hayashi, T. Nagatsu

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Abstract

We produced transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene. To investigate differences in the dopaminergic (DAergic) neuronal activity between the Tg and nTg mice, we examined changes in the locomotor activity induced by methamphetamine (MAP) and nicotine (NIC), which enhances DA release and induces TH enzyme activation, respectively. Surprisingly, however, the intensity of MAP (2.5 mg/kg, once a day for 14 days)-induced hyperlocomotion in the nTg mice was greater than that in the Tg mice, and, furthermore, the Tg mice were less sensitive to subacute administration of NIC (0.5 mg/kg, once a day for 14 days) than the nTg mice. These results suggest that DAergic neuronal function is suppressed in Tg mice to compensate for the overexpression of TH.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalJournal of Neural Transmission
Volume97
Issue number1
DOIs
Publication statusPublished - 01-02-1994
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Nabeshima, T., Itoh, A., Kobayashi, K., Morita, S., Mizuguchi, T., Sawada, H., Nitta, A., Hasegawa, T., Hayashi, K., & Nagatsu, T. (1994). Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene. Journal of Neural Transmission, 97(1), 41-49. https://doi.org/10.1007/BF01277961