TY - JOUR
T1 - Effects of subacute administration of methamphetamine and nicotine on locomotor activity in transgenic mice expressing the human tyrosine hydroxylase gene
AU - Nabeshima, T.
AU - Itoh, A.
AU - Kobayashi, K.
AU - Morita, S.
AU - Mizuguchi, T.
AU - Sawada, H.
AU - Nitta, A.
AU - Hasegawa, T.
AU - Hayashi, K.
AU - Nagatsu, T.
PY - 1994/2
Y1 - 1994/2
N2 - We produced transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene. To investigate differences in the dopaminergic (DAergic) neuronal activity between the Tg and nTg mice, we examined changes in the locomotor activity induced by methamphetamine (MAP) and nicotine (NIC), which enhances DA release and induces TH enzyme activation, respectively. Surprisingly, however, the intensity of MAP (2.5 mg/kg, once a day for 14 days)-induced hyperlocomotion in the nTg mice was greater than that in the Tg mice, and, furthermore, the Tg mice were less sensitive to subacute administration of NIC (0.5 mg/kg, once a day for 14 days) than the nTg mice. These results suggest that DAergic neuronal function is suppressed in Tg mice to compensate for the overexpression of TH.
AB - We produced transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene. To investigate differences in the dopaminergic (DAergic) neuronal activity between the Tg and nTg mice, we examined changes in the locomotor activity induced by methamphetamine (MAP) and nicotine (NIC), which enhances DA release and induces TH enzyme activation, respectively. Surprisingly, however, the intensity of MAP (2.5 mg/kg, once a day for 14 days)-induced hyperlocomotion in the nTg mice was greater than that in the Tg mice, and, furthermore, the Tg mice were less sensitive to subacute administration of NIC (0.5 mg/kg, once a day for 14 days) than the nTg mice. These results suggest that DAergic neuronal function is suppressed in Tg mice to compensate for the overexpression of TH.
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U2 - 10.1007/BF01277961
DO - 10.1007/BF01277961
M3 - Article
C2 - 7888148
AN - SCOPUS:0028181148
VL - 97
SP - 41
EP - 49
JO - Acta Neurovegetativa
JF - Acta Neurovegetativa
SN - 0375-9245
IS - 1
ER -