Abstract
To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.
Original language | English |
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Pages (from-to) | 52-56 |
Number of pages | 5 |
Journal | Japanese Journal of Thoracic Diseases |
Volume | 34 |
Issue number | 1 |
Publication status | Published - 1996 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine