Effects of subacute hypoxia on alveolar epithelial ion transport in rats

S. Suzuki, Y. Hoshikawa, S. Ono, T. Sakuma, K. Koike, T. Tanita, S. Fujimura

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Abstract

To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue number1
Publication statusPublished - 26-03-1996
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Suzuki, S., Hoshikawa, Y., Ono, S., Sakuma, T., Koike, K., Tanita, T., & Fujimura, S. (1996). Effects of subacute hypoxia on alveolar epithelial ion transport in rats. Japanese Journal of Thoracic Diseases, 34(1), 52-56.