Effects of subacute hypoxia on alveolar epithelial ion transport in rats

S. Suzuki, Y. Hoshikawa, S. Ono, T. Sakuma, K. Koike, T. Tanita, S. Fujimura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.

Original languageEnglish
Pages (from-to)52-56
Number of pages5
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue number1
Publication statusPublished - 26-03-1996

Fingerprint

Ion Transport
Amiloride
Ouabain
Albumins
Down-Regulation
Lung
Hypoxia

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cite this

Suzuki, S., Hoshikawa, Y., Ono, S., Sakuma, T., Koike, K., Tanita, T., & Fujimura, S. (1996). Effects of subacute hypoxia on alveolar epithelial ion transport in rats. Japanese Journal of Thoracic Diseases, 34(1), 52-56.
Suzuki, S. ; Hoshikawa, Y. ; Ono, S. ; Sakuma, T. ; Koike, K. ; Tanita, T. ; Fujimura, S. / Effects of subacute hypoxia on alveolar epithelial ion transport in rats. In: Japanese Journal of Thoracic Diseases. 1996 ; Vol. 34, No. 1. pp. 52-56.
@article{bef9bc61d817407d9efd385ae2730666,
title = "Effects of subacute hypoxia on alveolar epithelial ion transport in rats",
abstract = "To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5{\%} bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.",
author = "S. Suzuki and Y. Hoshikawa and S. Ono and T. Sakuma and K. Koike and T. Tanita and S. Fujimura",
year = "1996",
month = "3",
day = "26",
language = "English",
volume = "34",
pages = "52--56",
journal = "Respiratory Investigation",
issn = "2212-5345",
publisher = "Elsevier BV",
number = "1",

}

Suzuki, S, Hoshikawa, Y, Ono, S, Sakuma, T, Koike, K, Tanita, T & Fujimura, S 1996, 'Effects of subacute hypoxia on alveolar epithelial ion transport in rats', Japanese Journal of Thoracic Diseases, vol. 34, no. 1, pp. 52-56.

Effects of subacute hypoxia on alveolar epithelial ion transport in rats. / Suzuki, S.; Hoshikawa, Y.; Ono, S.; Sakuma, T.; Koike, K.; Tanita, T.; Fujimura, S.

In: Japanese Journal of Thoracic Diseases, Vol. 34, No. 1, 26.03.1996, p. 52-56.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of subacute hypoxia on alveolar epithelial ion transport in rats

AU - Suzuki, S.

AU - Hoshikawa, Y.

AU - Ono, S.

AU - Sakuma, T.

AU - Koike, K.

AU - Tanita, T.

AU - Fujimura, S.

PY - 1996/3/26

Y1 - 1996/3/26

N2 - To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.

AB - To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.

UR - http://www.scopus.com/inward/record.url?scp=0029865480&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029865480&partnerID=8YFLogxK

M3 - Article

C2 - 8717291

AN - SCOPUS:0029865480

VL - 34

SP - 52

EP - 56

JO - Respiratory Investigation

JF - Respiratory Investigation

SN - 2212-5345

IS - 1

ER -