To study the effects of subacute hypoxia on alveolar epithelial ion transport, alveolar fluid clearance was measured in isolated fluid-filled rat lungs. After instillation of a solution containing about 5% bovine albumin, an increase in alveolar fluid clearance was measured over 2 hours. Alveolar fluid clearance was lower when rats were kept in hypoxic conditions (FiO2 = 0.1) for 48 hours. Neither 10-5 M amiloride (a Na+-channel blocker) nor 10-3 M ouabain (an inhibitor of Na+-K+-ATPase) inhibited fluid clearance in the hypoxia group, but they did in the normoxia group. These results indicate that subacute hypoxia may down-regulate both the Na+-channel and Na+-K+-ATPase, and thus decrease the absorption of excess alveolar fluid.
|Number of pages||5|
|Journal||Japanese Journal of Thoracic Diseases|
|Publication status||Published - 26-03-1996|
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine