Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature

Hirohisa Ishimaru; Toshitaka Nabeshima; Akira Katoh; Hirotaka Suzuki; Taneo Fukuta; Tsutomu Kameyama

doi:10.1016/0006-291X(91)91893-H

Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature

Hirohisa Ishimaru, Toshitaka Nabeshima, Akira Katoh, Hirotaka Suzuki, Taneo Fukuta, Tsutomu Kameyama

Research output: Contribution to journal › Article › peer-review

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Abstract

The 3 time carbon monoxide (CO) exposures potentiated the delayed neuronal death (DND) in comparison with that induced by single CO exposure. Deterioration of DND induced by CO exposures was observed when normal body temperature was maintained during the exposures, since CO exposure fell the body temperature to about 34°C. Pretreatment with noncompetitive NMDA receptor antagonist, MK-801 (30 nmol/mouse), ameliorated DND induced by successive CO exposures under the maintenance of normal body temperature. These results suggest that the mice exposed successively to CO under the maintenance of normal body temperature is a useful hypoxic model.

Original language	English
Pages (from-to)	836-840
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	179
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(91)91893-H
Publication status	Published - 16-09-1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(91)91893-H

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abstract = "The 3 time carbon monoxide (CO) exposures potentiated the delayed neuronal death (DND) in comparison with that induced by single CO exposure. Deterioration of DND induced by CO exposures was observed when normal body temperature was maintained during the exposures, since CO exposure fell the body temperature to about 34°C. Pretreatment with noncompetitive NMDA receptor antagonist, MK-801 (30 nmol/mouse), ameliorated DND induced by successive CO exposures under the maintenance of normal body temperature. These results suggest that the mice exposed successively to CO under the maintenance of normal body temperature is a useful hypoxic model.",

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AU - Ishimaru, Hirohisa

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AU - Suzuki, Hirotaka

AU - Fukuta, Taneo

AU - Kameyama, Tsutomu

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AB - The 3 time carbon monoxide (CO) exposures potentiated the delayed neuronal death (DND) in comparison with that induced by single CO exposure. Deterioration of DND induced by CO exposures was observed when normal body temperature was maintained during the exposures, since CO exposure fell the body temperature to about 34°C. Pretreatment with noncompetitive NMDA receptor antagonist, MK-801 (30 nmol/mouse), ameliorated DND induced by successive CO exposures under the maintenance of normal body temperature. These results suggest that the mice exposed successively to CO under the maintenance of normal body temperature is a useful hypoxic model.

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Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature

Abstract

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