Effects of successive carbon monoxide exposures on delayed neuronal death in mice under the maintenance of normal body temperature

Hirohisa Ishimaru, Toshitaka Nabeshima, Akira Katoh, Hirotaka Suzuki, Taneo Fukuta, Tsutomu Kameyama

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The 3 time carbon monoxide (CO) exposures potentiated the delayed neuronal death (DND) in comparison with that induced by single CO exposure. Deterioration of DND induced by CO exposures was observed when normal body temperature was maintained during the exposures, since CO exposure fell the body temperature to about 34°C. Pretreatment with noncompetitive NMDA receptor antagonist, MK-801 (30 nmol/mouse), ameliorated DND induced by successive CO exposures under the maintenance of normal body temperature. These results suggest that the mice exposed successively to CO under the maintenance of normal body temperature is a useful hypoxic model.

Original languageEnglish
Pages (from-to)836-840
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume179
Issue number2
DOIs
Publication statusPublished - 16-09-1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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