Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice

Toshitaka Nabeshima, Shigeru Yoshida, Tsutomu Kameyama

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The effects of NIK-247 [9-amino-2,3,5,6,7,8-hexahydro-1 H-cyclopenta(b)-quinoline monohydrate hydrochloride] were studied on a model involving various types of drug- and electroconvulsive shock (ECS)-induced amnesia. The step-down type passive avoidance task in mice was used for comparison of the affects with those of tacrine, a 4-aminopyridine derivative which has an antiamnesic action. NIK-247 administered pre- and post-training or pre-retention test (24 h after training) prevented the disruption of memory induced by cycloheximide administered immediately after training. In addition, NIK-247 protected from the amnesia induced by treatment with ECS, phencyclidine and picrotoxin immediately after training. Tacrine failed to protect from ECS- and PCP-induced amnesia at the doses effective on cycloheximide-induced amnesia. The results indicate that NIK-247 improves cognitive functions at different phases of the learning and memory processes such as acquisition, consolidation, and retrieval in drug- and ECS-induced amnesia. NIK-247 may produce its antiamnesic effects via the cholinergic and GABAergic neuronal systems.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalEuropean Journal of Pharmacology
Volume154
Issue number3
DOIs
Publication statusPublished - 23-09-1988
Externally publishedYes

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Amnesia
Electroshock
Tacrine
Cycloheximide
Phencyclidine
Picrotoxin
4-Aminopyridine
Pharmaceutical Preparations
Cognition
Cholinergic Agents
amiridine
Learning

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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Effects of the novel compound NIK-247 on impairment of passive avoidance response in mice. / Nabeshima, Toshitaka; Yoshida, Shigeru; Kameyama, Tsutomu.

In: European Journal of Pharmacology, Vol. 154, No. 3, 23.09.1988, p. 263-269.

Research output: Contribution to journalArticle

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