Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin

T. Hasegawa, K. I. Yamaki, I. Muraoka, M. Nadai, K. Takagi, T. Nabeshima

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The effects of single coadministrations of one of three traditional Chinese medicines, Hotyu-ekki-to, Rikkunshi-to, and Juzen-taiho-to, on the pharmacokinetics of levofloxacin (LVFX) were investigated with eight healthy volunteers in an open, random crossover fashion. Subjects each received a single oral dose of LVFX (200 mg) alone and then with a single coadministration of each Chinese medicine. There were no significant differences in any pharmacokinetic parameters of LVFX between the groups. Also, no significant changes in the urinary recovery (>80%) and renal clearance of LVFX were observed. These results indicate that the Chinese medicines tested have no significant effect on the rate and extent of bioavailability or renal excretion of LVFX.

Original languageEnglish
Pages (from-to)2135-2137
Number of pages3
JournalAntimicrobial agents and chemotherapy
Issue number9
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases


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