Effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species generation in vitro

H. Sasaki, H. Akamatsu, Y. Matoba, S. Ri, A. Ito, Y. Asada

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1 Citation (Scopus)

Abstract

The effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation were examined. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Tranexamic acid reduced the levels of O2- and OH· generated by neutrophils. On the other hand, the agent did not markedly affect neutrophil chemotaxis, phagocytosis and the ROS levels generated in a cell-free, xanthine-xanthine oxidase system. The present study is likely to suggest that tranexamic acid is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting neutrophil-derived ROS generation in tissues and organs, especially at the sites of inflammation.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalJapanese Pharmacology and Therapeutics
Volume22
Issue number3
Publication statusPublished - 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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