Effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species generation in vitro

H. Sasaki; H. Akamatsu; Y. Matoba; S. Ri; A. Ito; Y. Asada

Effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species generation in vitro

H. Sasaki, H. Akamatsu, Y. Matoba, S. Ri, A. Ito, Y. Asada

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Abstract

The effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation were examined. The species investigated were superoxide radical anion (O₂^-), hydrogen peroxide (H₂O₂) and hydroxyl radical (OH·). Tranexamic acid reduced the levels of O₂^- and OH· generated by neutrophils. On the other hand, the agent did not markedly affect neutrophil chemotaxis, phagocytosis and the ROS levels generated in a cell-free, xanthine-xanthine oxidase system. The present study is likely to suggest that tranexamic acid is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting neutrophil-derived ROS generation in tissues and organs, especially at the sites of inflammation.

Original language	English
Pages (from-to)	325-331
Number of pages	7
Journal	Japanese Pharmacology and Therapeutics
Volume	22
Issue number	3
Publication status	Published - 1994
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)

Cite this

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title = "Effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species generation in vitro",

abstract = "The effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation were examined. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Tranexamic acid reduced the levels of O2- and OH· generated by neutrophils. On the other hand, the agent did not markedly affect neutrophil chemotaxis, phagocytosis and the ROS levels generated in a cell-free, xanthine-xanthine oxidase system. The present study is likely to suggest that tranexamic acid is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting neutrophil-derived ROS generation in tissues and organs, especially at the sites of inflammation.",

author = "H. Sasaki and H. Akamatsu and Y. Matoba and S. Ri and A. Ito and Y. Asada",

year = "1994",

language = "English",

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T1 - Effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species generation in vitro

AU - Sasaki, H.

AU - Akamatsu, H.

AU - Matoba, Y.

AU - Ri, S.

AU - Ito, A.

AU - Asada, Y.

PY - 1994

Y1 - 1994

N2 - The effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation were examined. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Tranexamic acid reduced the levels of O2- and OH· generated by neutrophils. On the other hand, the agent did not markedly affect neutrophil chemotaxis, phagocytosis and the ROS levels generated in a cell-free, xanthine-xanthine oxidase system. The present study is likely to suggest that tranexamic acid is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting neutrophil-derived ROS generation in tissues and organs, especially at the sites of inflammation.

AB - The effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species (ROS) generation were examined. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H2O2) and hydroxyl radical (OH·). Tranexamic acid reduced the levels of O2- and OH· generated by neutrophils. On the other hand, the agent did not markedly affect neutrophil chemotaxis, phagocytosis and the ROS levels generated in a cell-free, xanthine-xanthine oxidase system. The present study is likely to suggest that tranexamic acid is not an ROS scavenger but exerts an anti-inflammatory action by inhibiting neutrophil-derived ROS generation in tissues and organs, especially at the sites of inflammation.

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AN - SCOPUS:0028220797

SN - 0386-3603

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JO - Japanese Pharmacology and Therapeutics

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ER -

Effects of tranexamic acid on neutrophil chemotaxis, phagocytosis and reactive oxygen species generation in vitro

Abstract

All Science Journal Classification (ASJC) codes

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