Effects of Various Amino Acids and Their Related Agents in Association with Neurotransmitter Substances on the Morphine-induced Straub Tail Reaction in Mice1

Tsutomu Kameyama, Makoto Ukai, Toshitaka Nabeshima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Experiments were carried out in an attempt to elucidate the effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction (STR) in mice, using intracerebral injection technique. γ-Aminobutyric acid (GABA) and aminooxyacetic acid yielded significant decrement of the STR. Bicuculline provided the significant increment of the STR. DL-γ-Amino-β-hydroxybutyric acid and γ-guanidinobutyric acid had no influence on the STR. Glycine and taurine inhibited the STR significantly. L-Glutamic acid, L-aspartic acid, L-tyrosine and L-tryptophan had no influence on the STR. These results suggested the possibility that GABA, glycine and taurine may prevent the morphine-induced STR by means of an inhibitory action on the central nervous system in mice.

Original languageEnglish
Pages (from-to)770-773
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume26
Issue number3
DOIs
Publication statusPublished - 01-01-1978

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Taurine
Glycine
gamma-Aminobutyric Acid
Morphine
Neurotransmitter Agents
Tail
Aminooxyacetic Acid
Hydroxybutyrates
Aminobutyrates
Amino Acids
Bicuculline
Neurology
Aspartic Acid
Tryptophan
Tyrosine
Amino acids
Glutamic Acid
Acids
Experiments
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

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abstract = "Experiments were carried out in an attempt to elucidate the effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction (STR) in mice, using intracerebral injection technique. γ-Aminobutyric acid (GABA) and aminooxyacetic acid yielded significant decrement of the STR. Bicuculline provided the significant increment of the STR. DL-γ-Amino-β-hydroxybutyric acid and γ-guanidinobutyric acid had no influence on the STR. Glycine and taurine inhibited the STR significantly. L-Glutamic acid, L-aspartic acid, L-tyrosine and L-tryptophan had no influence on the STR. These results suggested the possibility that GABA, glycine and taurine may prevent the morphine-induced STR by means of an inhibitory action on the central nervous system in mice.",
author = "Tsutomu Kameyama and Makoto Ukai and Toshitaka Nabeshima",
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