Abstract
Experiments were carried out in an attempt to elucidate the effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction (STR) in mice, using intracerebral injection technique. γ-Aminobutyric acid (GABA) and aminooxyacetic acid yielded significant decrement of the STR. Bicuculline provided the significant increment of the STR. DL-γ-Amino-β-hydroxybutyric acid and γ-guanidinobutyric acid had no influence on the STR. Glycine and taurine inhibited the STR significantly. L-Glutamic acid, L-aspartic acid, L-tyrosine and L-tryptophan had no influence on the STR. These results suggested the possibility that GABA, glycine and taurine may prevent the morphine-induced STR by means of an inhibitory action on the central nervous system in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 770-773 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 01-01-1978 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Drug Discovery
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Effects of Various Amino Acids and Their Related Agents in Association with Neurotransmitter Substances on the Morphine-induced Straub Tail Reaction in Mice1. / Kameyama, Tsutomu; Ukai, Makoto; Nabeshima, Toshitaka.
In: Chemical and Pharmaceutical Bulletin, Vol. 26, No. 3, 01.01.1978, p. 770-773.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of Various Amino Acids and Their Related Agents in Association with Neurotransmitter Substances on the Morphine-induced Straub Tail Reaction in Mice1
AU - Kameyama, Tsutomu
AU - Ukai, Makoto
AU - Nabeshima, Toshitaka
PY - 1978/1/1
Y1 - 1978/1/1
N2 - Experiments were carried out in an attempt to elucidate the effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction (STR) in mice, using intracerebral injection technique. γ-Aminobutyric acid (GABA) and aminooxyacetic acid yielded significant decrement of the STR. Bicuculline provided the significant increment of the STR. DL-γ-Amino-β-hydroxybutyric acid and γ-guanidinobutyric acid had no influence on the STR. Glycine and taurine inhibited the STR significantly. L-Glutamic acid, L-aspartic acid, L-tyrosine and L-tryptophan had no influence on the STR. These results suggested the possibility that GABA, glycine and taurine may prevent the morphine-induced STR by means of an inhibitory action on the central nervous system in mice.
AB - Experiments were carried out in an attempt to elucidate the effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction (STR) in mice, using intracerebral injection technique. γ-Aminobutyric acid (GABA) and aminooxyacetic acid yielded significant decrement of the STR. Bicuculline provided the significant increment of the STR. DL-γ-Amino-β-hydroxybutyric acid and γ-guanidinobutyric acid had no influence on the STR. Glycine and taurine inhibited the STR significantly. L-Glutamic acid, L-aspartic acid, L-tyrosine and L-tryptophan had no influence on the STR. These results suggested the possibility that GABA, glycine and taurine may prevent the morphine-induced STR by means of an inhibitory action on the central nervous system in mice.
UR - http://www.scopus.com/inward/record.url?scp=0017837062&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017837062&partnerID=8YFLogxK
U2 - 10.1248/cpb.26.770
DO - 10.1248/cpb.26.770
M3 - Article
C2 - 206369
AN - SCOPUS:0017837062
VL - 26
SP - 770
EP - 773
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 3
ER -