Effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by the basal forebrain lesion in rats

Hiroshi Kinoshita, Tsutomu Kameyama, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by the basal forebrain (BF) lesion in rats. Bilateral BF lesions were produced by injecting ibotenic acid (6 μg/0.5 μl/side). In BF-lesioned rats, impairment of spatial learning in escaping onto the platform during training and decrease in spatial bias during the spatial probe trial in Morri's water maze task were both observed. Vinconate (5 and 10 mg/kg) treatment shortened the increase of escape latency to the platform in BF-lesioned rats and significantly reversed the decrease in spatial bias induced by the BF lesion. Vinconate (10 mg/kg) attenuated the decrease in choline acetyltransferase activity in the frontoparietal cortex caused by the BF lesion. The present study suggests that vinconate has an antiamnesic effect on the BF-lesion-induced amnesia by ameliorating the dysfunction in cholinergic neurons.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume42
Issue number1
DOIs
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

Vinca Alkaloids
Rats
Ibotenic Acid
Choline O-Acetyltransferase
Cholinergic Agents
Neurons
Cholinergic Neurons
Amnesia
vinconate
Spatial Learning
Basal Forebrain
Water

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

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abstract = "We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by the basal forebrain (BF) lesion in rats. Bilateral BF lesions were produced by injecting ibotenic acid (6 μg/0.5 μl/side). In BF-lesioned rats, impairment of spatial learning in escaping onto the platform during training and decrease in spatial bias during the spatial probe trial in Morri's water maze task were both observed. Vinconate (5 and 10 mg/kg) treatment shortened the increase of escape latency to the platform in BF-lesioned rats and significantly reversed the decrease in spatial bias induced by the BF lesion. Vinconate (10 mg/kg) attenuated the decrease in choline acetyltransferase activity in the frontoparietal cortex caused by the BF lesion. The present study suggests that vinconate has an antiamnesic effect on the BF-lesion-induced amnesia by ameliorating the dysfunction in cholinergic neurons.",
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Effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by the basal forebrain lesion in rats. / Kinoshita, Hiroshi; Kameyama, Tsutomu; Hasegawa, Takaaki; Nabeshima, Toshitaka.

In: Pharmacology, Biochemistry and Behavior, Vol. 42, No. 1, 01.01.1992, p. 19-23.

Research output: Contribution to journalArticle

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