Abstract
We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 267-273 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 51 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1992 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats. / Kinoshita, Hiroshi; Kameyana, Tsutomu; Hasegawa, Takaaki; Nabeshima, Toshitaka.
In: Life Sciences, Vol. 51, No. 4, 1992, p. 267-273.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats
AU - Kinoshita, Hiroshi
AU - Kameyana, Tsutomu
AU - Hasegawa, Takaaki
AU - Nabeshima, Toshitaka
PY - 1992
Y1 - 1992
N2 - We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.
AB - We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.
UR - http://www.scopus.com/inward/record.url?scp=0026651089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026651089&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(92)90085-4
DO - 10.1016/0024-3205(92)90085-4
M3 - Article
C2 - 1625518
AN - SCOPUS:0026651089
VL - 51
SP - 267
EP - 273
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 4
ER -