Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats

Hiroshi Kinoshita, Tsutomu Kameyana, Takaaki Hasegawa, Toshitaka Nabeshima

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalLife Sciences
Volume51
Issue number4
DOIs
Publication statusPublished - 1992

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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