Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats

Hiroshi Kinoshita; Tsutomu Kameyana; Takaaki Hasegawa; Toshitaka Nabeshima

doi:10.1016/0024-3205(92)90085-4

Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats

Hiroshi Kinoshita, Tsutomu Kameyana, Takaaki Hasegawa, Toshitaka Nabeshima

Research Division of Advanced Diagnostic System

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.

Original language	English
Pages (from-to)	267-273
Number of pages	7
Journal	Life Sciences
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(92)90085-4
Publication status	Published - 1992

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(92)90085-4

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title = "Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats",

abstract = "We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.",

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AU - Kinoshita, Hiroshi

AU - Kameyana, Tsutomu

AU - Hasegawa, Takaaki

AU - Nabeshima, Toshitaka

PY - 1992

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N2 - We investigated the effects of vinconate, a novel vinca alkaloid, on spatial learning deficits induced by medial septal (MS) lesion rats. MS lesion was produced by passing an anodal DC current. In vehicle-treated MS-lesioned rats impairment of spatial learning was observed, shown by a decrease in correct choices and an increase in total errors during training in a radial arm maze task. Vinconate (10 mg/kg) treatment alleviated the decrease in correct choices and the increase in total erros induced by MS lesion. Vinconate (5 and 10 mg/kg) treatment showed a tendency to reverse the decrease in choline acetyltrasnferase activity in the hippocampus caused by MS lesion. The present study suggests that vinconate has an anti-amnesic effect on MS lesion-induced amnesia by ameliorating the dysfunction in cholinergic (ACh) neurons.

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