Effects of Yoku-kan-san-ka-chimpi-hange on the sleep of normal healthy adult subjects

Rika Aizawa, Takashi Kanbayashi, Yasushi Saito, Yuriko Ogawa, Tomonari Sugiyama, Tsuyoshi Kitajima, Yoshihiko Kaneko, Masahito Abe, Tetsuo Shimizu

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46 Citations (Scopus)


Yoku-kan-san-ka-chimpi-hange (YKCH) is a drug used for insomnia in Japanese traditional herbal medicine. The present study evaluated the effects of YKCH on sleep by all-night polysomnography using the double-blind method. Yoku-kan-san-ka-chimpi-hange increased the total sleep time significantly, and tended to cause an increase in sleep efficiency and of stage 2 sleep, as well as a decrease of sleep latency and of stage 3 + 4 sleep. There was no apparent influence on rapid eye movement (REM) sleep. In terms of non-REM sleep, the effects of YKCH exhibit a profile similar to those of benzodiazepines.

Original languageEnglish
Pages (from-to)303-304
Number of pages2
JournalPsychiatry and clinical neurosciences
Issue number3
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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